지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 298 - 304 (7page)
이용수
초록· 키워드
오류제보하기
The activation of nuclear factor-kappa B1 (NFκB1) in cancer cells may confer resistance to ionizing radiation (IR). To enhance the therapeutic efficiency of IR in lung cancer, we screened for microRNAs (miRNAs)that suppress NFκB1 and observed their effects on radiosensitivity in a human lung cancer cell line. From time series data of miRNA expression in γ-irradiated H1299 human lung cancer cells, we found that the expression of miR-9 was inversely correlated with that of NFκB1. Overexpression of miR-9 down-regulated the level of NFκB1 in H1299 cells, and the surviving fraction of γ-irradiated cells was decreased. Interestingly,let-7g also suppressed the expression of NFκB1, although there was no canonical target site for let-7g in the NFκB1 3' untranslated region. From these results,we conclude that the expression of miR-9 and let-7g could enhance the efficiency of radiotherapy for lung cancer treatment through the inhibition of NFκB1.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Aggarwal BB / 2009 / Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe / Clin Cancer Res 15 : 425 ~ 430
Amundson SA / 2003 / Functional genomics as a window on radiation stress signaling / Oncogene 22 : 5828 ~ 5833
Amundson SA / 2008 / Functional genomics in radiation biology: a gateway to cellular systems-level studies / Radiat Environ Biophys 47 : 25 ~ 31
Bazzoni F / 2009 / Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals / Proc Natl Acad Sci 106 : 5282 ~ 5287
Chaudhry MA / 2010 / Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity / Int J Radiat Biol 86 : 569 ~ 583
Amundson SA / 2003 / Functional genomics as a window on radiation stress signaling / Oncogene 22 : 5828 ~ 5833
Amundson SA / 2008 / Functional genomics in radiation biology: a gateway to cellular systems-level studies / Radiat Environ Biophys 47 : 25 ~ 31
Bazzoni F / 2009 / Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals / Proc Natl Acad Sci 106 : 5282 ~ 5287
Chaudhry MA / 2010 / Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity / Int J Radiat Biol 86 : 569 ~ 583
이 논문의 저자 정보
최근 본 자료
댓글(0)
0