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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제5호
- 발행연도
- 2006.1
- 수록면
- 757 - 763 (7page)
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초록· 키워드
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Angiotensin I-converting enzyme (ACE) inhibitorshave generally been very useful to remedy or prevent hypertension.This study describes the extraction and characterization of anACE inhibitor from the fruiting body of Pholiota adiposa ASI24012, which can be used as an antihypertensive drug. The50; 0.25 mg) was obtainedwhen the fruiting body of Pholiota adiposa ASI 24012 wasextracted with distilled water at 30oC for 12 h. After thepurification of ACE inhibitor with ultrafiltration, SephadexG-25 column chromatography, and reverse-phase HPLC, anactive fraction with an IC50 of 0.04 mg was obtained. Thepurified ACE inhibitory peptide was a novel pentapeptide,showing very little similarity to other ACE inhibitory peptidewas estimated to be 414 daltons with a sequence of Gly-Glu-Gly-Gly-Pro, and showed a clear antihypertensive effect onspontaneously hypertensive rats (SHR) at a dosage of 1 mg/kg.
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참고문헌 (25)
참고문헌 신청
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Arihara, K / 2001 / Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle proteins / Meat Sci. 57 : 319 ~ 324
Ariyosh, Y / 1993 / Angiotensin converting enzyme inhibitors derived from food protein / Trends Food Sci. Technol. 4 : 139 ~ 144
Astawan, M / 1995 / Effects of angiotensin-I converting enzyme inhibitory substance derived from Indonesian dried-salted fish on blood pressure of rats / Biosci. Biotechnol.
Athukorala, Y / 2005 / Screening for angiotensin I-converting enzyme inhibitory activity of Ecklonia cava / Korean J. Food Sci. Nutr. 10 : 134 ~ 139
Arihara, K / 2001 / Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle proteins / Meat Sci. 57 : 319 ~ 324
Ariyosh, Y / 1993 / Angiotensin converting enzyme inhibitors derived from food protein / Trends Food Sci. Technol. 4 : 139 ~ 144
Astawan, M / 1995 / Effects of angiotensin-I converting enzyme inhibitory substance derived from Indonesian dried-salted fish on blood pressure of rats / Biosci. Biotechnol.
Athukorala, Y / 2005 / Screening for angiotensin I-converting enzyme inhibitory activity of Ecklonia cava / Korean J. Food Sci. Nutr. 10 : 134 ~ 139
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