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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제23권 제8호
- 발행연도
- 2013.1
- 수록면
- 1,154 - 1,158 (5page)
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초록· 키워드
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Ganciclovir resistance of human cytomegalovirus is associated with mutations in the viral UL97 gene and poses severe problems for immunocompromised patients. In this study, PCRbased restriction fragment length polymorphism and sequencing analyses detected the UL97D605E mutation in all five clinical isolates from patients with ganciclovir-resistant human cytomegalovirus infection during prolonged ganciclovir therapy, whereas the M460V mutation was only present in 1 of 5 isolates. On the other hand, the detection rates of the D605E mutation in the stored available DNA samples from the donor and allogeneic stem cell transplantation recipients were 66.7% and 93.7%, respectively, suggesting that the presence of D605E mutation was not associated with the ganciclovir exposure. Although the D605E mutation may not be related to ganciclovir resistance, we suggest that this mutation could be an important molecular marker of human cytomegalovirus evolution in East Asian countries.
Moreover, the restriction fragment length polymorphism method using the restriction enzyme HaeIII, which is generally used to detect the UL97 A591V mutation, could also detect the D605E mutation and may therefore be a useful tool for future research on the investigation of UL97 gene mutations.
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참고문헌 (20)
참고문헌 신청
Alain S / 1995 / Value of a new rapid non-radioactive sequencing method for analysis of the cytomegalovirus UL97 gene in ganciclovir-resistant strains / J. Virol. Methods 51
Centers for Disease Control and Prevention / 2000 / Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients: recommendations of
Chou S / 1995 / Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance
Chou S / 1995 / Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates / J. Infect. Dis 172 : 239 ~ 242
Chou S / 1997 / Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease / J. Infect. Dis 176 : 786 ~ 789
Centers for Disease Control and Prevention / 2000 / Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients: recommendations of
Chou S / 1995 / Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance
Chou S / 1995 / Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates / J. Infect. Dis 172 : 239 ~ 242
Chou S / 1997 / Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease / J. Infect. Dis 176 : 786 ~ 789
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