지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제1호
- 발행연도
- 2018.1
- 수록면
- 115 - 121 (7page)
이용수
초록· 키워드
오류제보하기
Upon sensing of microbial infections or endogenous danger signals in macrophages, inflammasome signaling plays a significant role in triggering inflammatory responses via producing interleukin (IL)-1β. Recent studies revealed that active caspase-1, a product of the inflammasome complex, causes maturation of inactive pro-IL-1β into the active form. However, the underlying mechanism by which this leaderless cytokine is secreted into the extracellular space remains to be elucidated. In this study, we demonstrated that prolonged lipopolysaccharide (LPS) treatment to macrophages could trigger the unexpected maturation and extracellular release of IL-1β through a nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3)-independent manner. Short-term treatment (less than 6 h) of LPS induced robust production of the IL-1β precursor form inside cells but did not promote the maturation and secretion of IL-1β in bone marrow-derived macrophages or peritoneal macrophages. Instead, prolonged LPS treatment (more than 12 h) led to a significant release of matured IL-1β with no robust indication of caspase-1 activation. Intriguingly, this LPS-triggered secretion of IL-1β was also observed in NLRP3-deficient macrophages. In addition, this unexpected IL-1β release was only partially impaired by a caspase-1 and NLRP3 inflammasome inhibitor. Collectively, our results propose that prolonged exposure to LPS is able to drive the maturation and secretion of IL-1β in an NLRP3 inflammasome-independent manner.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Dinarello CA / 2011 / Interleukin-1 in the pathogenesis and treatment of inflammatory diseases / Blood 117:3720~3732
Rubartelli A / 1990 / A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence / EMBO J 9:1503~1510
Thornberry NA / 1992 / A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes / Nature 356:768~774
Keller M / 2008 / Active caspase-1 is a regulator of unconventional protein secretion / Cell 132:818~831
Agostini L / 2004 / NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder / Immunity 20:319~325
Rubartelli A / 1990 / A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence / EMBO J 9:1503~1510
Thornberry NA / 1992 / A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes / Nature 356:768~774
Keller M / 2008 / Active caspase-1 is a regulator of unconventional protein secretion / Cell 132:818~831
Agostini L / 2004 / NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder / Immunity 20:319~325
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
NLRP3 인플라마좀 작용 기전 및 신경 질환에서의 역할
생명과학회지
2021 .02
-
RAW 264.7 대식세포에서 마늘 유래 황 함유 화합물에 의한 요산 유도 inflammasome 활성화의 억제는 ROS 생성 차단과 연관성이 있음
생명과학회지
2023 .04
-
갯까치수염 추출물에 의한 대식세포 염증반응과 NLRP3 inflammasome 활성화 억제활성 및 세포 내 기전 해석
생명과학회지
2025 .01
-
Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte
Journal of Microbiology and Biotechnology
2021 .01
-
A20 Protects Against Arthritis by Regulation of the NLRP3 Inflammasome
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .09
-
Cigarette Smoke Extract Enhances IL-17A-Induced IL-8 Production via Up-Regulation of IL-17R in Human Bronchial Epithelial Cells
Molecules and Cells
2018 .03
-
Cell-Based IL-15:IL-15Rα Secreting Vaccine as an Effective Therapy for CT26 Colon Cancer in Mice
Molecules and Cells
2019 .01
-
NLRP3 Inflammasome Activation during Mycobacterial Infection in Murine Microglia
한국미생물학회 학술대회논문집
2015 .04
-
Interleukin-9 Inhibits Lung Metastasis of Melanoma through Stimulating Anti-Tumor M1 Macrophages
Molecules and Cells
2020 .01
-
ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages
Genes & Genomics
2024 .03
-
Ficus vasculosa Wall. ex Miq. Inhibits the LPS-Induced Inflammation in RAW264.7 Macrophages
한국미생물·생명공학회지
2022 .12
-
LPS-stimulated Macrophage Activation Affects Endothelial Dysfunction
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2018 .03
-
The Inhibitory Effect of NLRP3 Deficiency in Hepatocellular Carcinoma SK-Hep1 Cells
한국미생물·생명공학회지
2021 .12
-
NMAAP1 Expressed in BCG-Activated Macrophage Promotes M1 Macrophage Polarization
Molecules and Cells
2015 .10
-
Efficient Interleukin-21 Production by Optimization of Codon and Signal Peptide in Chinese Hamster Ovarian Cells
Journal of Microbiology and Biotechnology
2019 .01
-
Caspase-8 Potentiates Triglyceride (TG)-Induced Cell Death of THP-1 Macrophages via a Positive Feedback Loop
대한임상검사과학회지
2021 .01
-
In Vitro GATA-3-Mediated Inhibition of IL-1ß, IL-6 and IL-10 Expression in Allergy Caused by Bisphenol A by Lactobacillus plantarum L67 Extract
한국미생물학회 학술대회논문집
2015 .04
-
Anti-Inflammatory Role of TAM Family of Receptor Tyrosine Kinases Via Modulating Macrophage Function
Molecules and Cells
2019 .01
-
Immunostimulatory Effect of Heat-Killed Probiotics on RAW264.7 Macrophages
Journal of Microbiology and Biotechnology
2022 .05
-
Anti-inflammatory effects of rutin in lipopolysaccharide-stimulated canine macrophage cells
Nutrition Research and Practice
2025 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0