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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1 - 6 (6page)
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Background: Our previous study had identified the SNP (g.81966377T > C) and indel (g.81966364D > I) located in the promoter of APM1 to have a significant effect on marbling in Hanwoo. APM1 encodes an adipocytokine called adiponectin, which plays a significant role in lipogenesis. The aim of this study was to verify and validate the effect of the SNP and indel on marbling and other carcass traits in a large, representative, countrywide population of Hanwoo cattle. The carcass traits measured were marbling (MAR), backfat thickness (BFT), loin eye area (LEA), and carcass weight (CAW).
Results: Primers were designed to amplify 346 bp of the genomic segment that contained the targeted SNP (g.81966377) and the indel (g.81966364). After data curation, the genotypes of 8,378 individuals identified using direct sequencing analysis estimated frequencies for C (0.686) and T (0.314) respectively showing genotype frequencies for CC (0.470), CT (0.430) and TT (0.098). The genotypes were significantly associated with MAR, BFT and LEA. The indel had significant effect on marbling (P < .0001) with strong additive genetic effects. The allele frequencies was estimated at (DEL, 0.864) and insertion (INS, 0.136) presenting genotypes of D/D (75.63 %), D/I (21.44 %), and I/I (2.92 %). Significant departure from Hardy-Weinberg equilibrium was not detected for both the SNP and the indel.
Conclusion: The SNP genotypes showed significant association with MAR, BFT and LEA with strong additive genetic effects, while the indel was significantly associated with MAR. The results confirmed that the variants can be used as a genetic marker for improving marbling in Hanwoo.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Berg AH / 2002 / ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism / Trends Endocrinol Metab 13(2):84~89
N. S. Morsci / 2006 / Association analysis of adiponectin and somatostatin polymorphisms on BTA1 with growth and carcass traits in Angus cattle / Animal Genetics 37(6):554~562
Piñeiro R / 2005 / Adiponectin is synthesized and secreted by human and murine cardiomyocytes / FEBS Lett 579(23):5163~5169
Scherer PE / 1995 / A novel serum protein similar to C1q, produced exclusively in adipocytes / J Biol Chem 270(45):26746~26749
Yokota T / 2002 / Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins / J Clin Invest 109(10):1303~1310
N. S. Morsci / 2006 / Association analysis of adiponectin and somatostatin polymorphisms on BTA1 with growth and carcass traits in Angus cattle / Animal Genetics 37(6):554~562
Piñeiro R / 2005 / Adiponectin is synthesized and secreted by human and murine cardiomyocytes / FEBS Lett 579(23):5163~5169
Scherer PE / 1995 / A novel serum protein similar to C1q, produced exclusively in adipocytes / J Biol Chem 270(45):26746~26749
Yokota T / 2002 / Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins / J Clin Invest 109(10):1303~1310
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