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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Methylglyoxal reductase Gre2 converts methylglyoxal to lactaldehyde, using either NADH or NADPH as electron donor,to protect cells from the cytotoxic effects of methylglyoxal. Gre2 belongs to the short-chain dehydrogenase/reductasesuperfamily, which exhibits considerable variation in its substrate binding clefts to catalyze a broad range of substrates. In this study, to understand the structural features and molecular mechanism of Gre2, we overexpressed, purified, andcrystallized the N-terminal His6-tagged Gre2 protein from Candida albicans and obtained X-ray diffraction data at aresolution of 2.8 Å. The C. albicans Gre2 crystal belongs to space group I23 with unit cell parameters a = b = c = 149.6 Å, α= β = γ = 90º. There is one molecule in the asymmetric unit.
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참고문헌 (17)
참고문헌 신청
Adams, P. D. / 2010 / PHENIX : a comprehensive Python-based system for macromolecular structure solution / Acta Crystallogr D Biol Crystallogr 66:213~221
Akita, H / 2015 / Characterization of the Kluyveromyces marxianus strain DMB1 YGL157w gene product as a broad specificity NADPH-dependent aldehyde reductase / AMB Express 5:17
Breicha, K. / 2010 / Crystallization and preliminary crystallographic analysis of Gre2p, an NADP+-dependent alcohol dehydrogenase from Saccharomyces cerevisiae / Acta Crystallogr Sect F Struct Biol Cryst Commun 66:838~841
Dafre, A. L. / 2015 / Methylglyoxal, the foe and friend of glyoxalase and Trx/TrxR systems in HT22 nerve cells / Free Radic Biol Med 89:8~19
Emsley, P. / 2004 / Coot : model-building tools for molecular graphics / Acta Crystallogr D Biol Crystallogr 60:2126~2132
Akita, H / 2015 / Characterization of the Kluyveromyces marxianus strain DMB1 YGL157w gene product as a broad specificity NADPH-dependent aldehyde reductase / AMB Express 5:17
Breicha, K. / 2010 / Crystallization and preliminary crystallographic analysis of Gre2p, an NADP+-dependent alcohol dehydrogenase from Saccharomyces cerevisiae / Acta Crystallogr Sect F Struct Biol Cryst Commun 66:838~841
Dafre, A. L. / 2015 / Methylglyoxal, the foe and friend of glyoxalase and Trx/TrxR systems in HT22 nerve cells / Free Radic Biol Med 89:8~19
Emsley, P. / 2004 / Coot : model-building tools for molecular graphics / Acta Crystallogr D Biol Crystallogr 60:2126~2132
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