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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. In this review, we expound what is known about the influence of clinical variables and related genetic risk factors on ischemic stroke outcome, focusing on acute and subacute outcome (within 24 to 48 hours after stroke and until day 10, respectively), as they are the first indicators of stroke damage. We searched the PubMed data base for articles that investigated the interaction between clinical variables or genetic factors and acute or subacute stroke outcome. A total of 61 studies were finally included in this review. Regarding the data collected, the variables consistently associated with acute stroke outcome are: glucose levels, blood pressure, presence of atrial fibrillation, prior statin treatment, stroke severity, type of acute treatment performed, severe neurological complications, leukocyte levels, and genetic risk factors. Further research and international efforts are required in this field, which should include genome-wide association studies.
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등록된 정보가 없습니다.
참고문헌 (83)
참고문헌 신청
Saposnik G / 2011 / IScore: a risk score to predict death early after hospitalization for an acute ischemic stroke / Circulation 123:739~749
Ibrahim-Verbaas CA / 2014 / Predicting stroke through genetic risk functions: the CHARGE Risk Score Project / Stroke 45:403~412
Bevan S / 2012 / Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations / Stroke 43:3161~3167
Traylor M / 2012 / Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies / Lancet Neurol 11:951~962
NINDS Stroke Genetics Network / 2016 / Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study / Lancet Neurol 15:174~184
Ibrahim-Verbaas CA / 2014 / Predicting stroke through genetic risk functions: the CHARGE Risk Score Project / Stroke 45:403~412
Bevan S / 2012 / Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations / Stroke 43:3161~3167
Traylor M / 2012 / Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies / Lancet Neurol 11:951~962
NINDS Stroke Genetics Network / 2016 / Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study / Lancet Neurol 15:174~184
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