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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 218 - 222 (5page)
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초록· 키워드
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Red blood cell (RBC) alloimmunization varies across human populations and ethnic groups. We evaluated the characteristics of RBC alloimmunization and compared the risk of alloimmunization in Korean patients with myelodysplastic syndrome (MDS) and liver cirrhosis (LC), two representative diseases in which chronic transfusion is required. In total, 115 MDS patients and 202 LC patients transfused with RBCs between 2013 and 2015 were retrospectively included. Twenty patients (6.3%) were newly alloimmunized (five MDS patients, 4.3%; 15 LC patients, 7.4%). The median number of RBC units transfused in alloimmunized patients was nine (interquartile range, 4–15 units). As the number of transfused RBC units increased, the cumulative risk of alloimmunization was higher in LC than in MDS patients (P=0.001). The most common alloantibody detected in patients was anti-E (45%), followed by anti-c (17%), anti-e (10%), anti-C (7%), anti-Fyb (7%), and anti-Jka (7%). The present data indicate the need for matching of extended RBC antigens (Rh, Duffy, and Kidd systems) for chronically transfused patients with MDS and LC in Korea.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Schonewille H / 2006 / Red blood cell alloantibodies after transfusion : factors influencing incidence and specificity / Transfusion 46:250~256
Lin Y / 2017 / Prophylactic RhCE and Kell antigen matching : impact on alloimmunization in transfusion-dependent patients with myelodysplastic syndromes / Vox Sang 112:79~86
Gehrie EA / 2014 / The influence of clinical and biological factors on transfusion-associated non-ABO antigen alloimmunization : responders, hyper-responders, and non-responders / Transfus Med Hemother 41:420~429
Evers D / 2016 / Red cell alloimmunisation in patients with different types of infections / Br J Haematol 175:956~966
Bauer MP / 2007 / Clinical predictors of alloimmunization after red blood cell transfusion / Transfusion 47:2066~2071
Lin Y / 2017 / Prophylactic RhCE and Kell antigen matching : impact on alloimmunization in transfusion-dependent patients with myelodysplastic syndromes / Vox Sang 112:79~86
Gehrie EA / 2014 / The influence of clinical and biological factors on transfusion-associated non-ABO antigen alloimmunization : responders, hyper-responders, and non-responders / Transfus Med Hemother 41:420~429
Evers D / 2016 / Red cell alloimmunisation in patients with different types of infections / Br J Haematol 175:956~966
Bauer MP / 2007 / Clinical predictors of alloimmunization after red blood cell transfusion / Transfusion 47:2066~2071
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