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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제53권 제2호
- 발행연도
- 2019.1
- 수록면
- 136 - 141 (6page)
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초록· 키워드
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Although papillary thyroid carcinoma (PTC)–type nuclear changes are the most reliable morphological feature in the diagnosis of PTC, the nuclear assessment used to identify these changes is highly subjective. Here, we report a noninvasive encapsulated thyroid tumor with a papillary growth pattern measuring 23 mm at its largest diameter with a nuclear score of 2 in a 26-year-old man. After undergoing left lobectomy, the patient was diagnosed with an encapsulated PTC. However, a second opinion consultation suggested an alternative diagnosis of follicular adenoma with papillary hyperplasia. When providing a third opinion, we identified a low MIB-1 labeling index and a heterozygous point mutation in the KRAS gene but not the BRAF gene. We speculated that this case is an example of a novel borderline tumor with a papillary structure. Introduction of the new terminology “noninvasive encapsulated papillary RAS-like thyroid tumor (NEPRAS)” without the word “cancer” might relieve the psychological burden of patients in a way similar to the phrase “noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).”
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참고문헌 (20)
참고문헌 신청
Pappotti M / 2017 / WHO classification of tumours of endocrine organs / International Agency for Research on Cance :73~74
Chan JK / 2017 / WHO classification of tumours of endocrine organs / International Agency for Research on Cancer :76~77
Nikiforov YE / 2017 / Who classification of tumours of endocrine organs / International Agency for Research on Cancer :78~80
Nikiforov YE / 2016 / Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma : a paradigm shift to reduce overtreatment of indolent tumors / JAMA Oncol 2:1023~1029
Rosai J / 2003 / Renaming papillary microcarcinoma of the thyroid gland : the Porto proposal / Int J Surg Pathol 11:249~251
Chan JK / 2017 / WHO classification of tumours of endocrine organs / International Agency for Research on Cancer :76~77
Nikiforov YE / 2017 / Who classification of tumours of endocrine organs / International Agency for Research on Cancer :78~80
Nikiforov YE / 2016 / Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma : a paradigm shift to reduce overtreatment of indolent tumors / JAMA Oncol 2:1023~1029
Rosai J / 2003 / Renaming papillary microcarcinoma of the thyroid gland : the Porto proposal / Int J Surg Pathol 11:249~251
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Association Between <sup>18</sup>F-FDG Avidity and the BRAF Mutation in Papillary Thyroid Carcinoma
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Expressions of miRNAs in Papillary Thyroid Carcinoma and Their Associations with the BRAFV600EMutation and Clinicopathological Features.
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Diagnostic Clinicopathological Parameters for Predicting Non-invasive Follicular Thyroid Neoplasm with Papillary Features (NIFTP)
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Cohexisting Medullary and Papillary Thyroid Cancer
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