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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제53권 제3호
- 발행연도
- 2019.1
- 수록면
- 153 - 158 (6page)
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Liquid biopsy for detection of mutation from circulating tumor DNA is a new technology which is attractive in that it is non-invasive. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) is an effective first line drug for advanced non-small cell lung cancer patients who harbor activating EGFR mutation. During the course of treatment, resistance against TKI arises which can be contributed to EGFR T790M mutation in about 50–60% of patients. Third generation TKI may overcome the resistance. In patients who cannot undergo tissue biopsy due to variable reasons, liquid biopsy is an excellent alternative for the detection of EGFR T790M mutation. However, this relatively novel method requires standardization and vigorous quality insurance. Thus, a standard set of guideline recommendations for liquid biopsy for EGFR mutation testing suitable for the Korean medical community is necessary. In this article, we propose a set of provisional guideline recommendations that was discussed and approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.
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참고문헌 (32)
참고문헌 신청
Lynch TJ / 2004 / Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib / N Engl J Med 350:2129~2139
Paez JG / 2004 / EGFR mutations in lung cancer : correlation with clinical response to gefitinib therapy / Science 304:1497~1500
Mok TS / 2009 / Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma / N Engl J Med 361:947~957
Balak MN / 2006 / Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors / Clin Cancer Res 12:6494~6501
Thress KS / 2015 / Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M / Nat Med 21:560~562
Paez JG / 2004 / EGFR mutations in lung cancer : correlation with clinical response to gefitinib therapy / Science 304:1497~1500
Mok TS / 2009 / Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma / N Engl J Med 361:947~957
Balak MN / 2006 / Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors / Clin Cancer Res 12:6494~6501
Thress KS / 2015 / Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M / Nat Med 21:560~562
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