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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 368 - 377 (10page)
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Purpose Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a rare subtype of non- Hodgkin lymphoma, and asparaginase-based regimens are the best first-line treatments. Data on the role of specific circulating lymphocyte subsets in the progression of ENKTL are limited. The aim of this study was to investigate the clinical correlation and distribution of circulating absolute CD4+ T-cell counts (ACD4Cs) in ENKTL. Materials and Methods We retrospectively searched medical records for 70 newly diagnosed ENKTL patients treated with pegaspargase-based regimens. Comparison of ACD4Cs as a continuous parameter in different groups was calculated. Univariate and multivariate analyses were used to assess prognostic factors for overall survival (OS) and progression-free survival (PFS). Results Stage III/IV, B symptoms, elevated lactate dehydrogenase, monocytopenia, high-intermediate and high risk International Prognostic Index (IPI) and Korean Prognostic Index (KPI), high risk Prognostic Index of Natural Killer Lymphoma (PINK), and lower lymphocytes were significantly associated with low ACD4C at diagnosis. With a median follow-up time of 32 months, patients who had an ACD4C < 0.30109/L had a worse OS. Median OS was 11 months and median PFS was 5 months in the low ACD4C cohort. There were significant differences in both OS and PFS between the two cohorts. Moreover, multivariate Cox analysis identified ACD4Cs as an independent predictor for OS and PFS. Conclusion Low ACD4Cs were associated with poorer survival and could act as a negative predictor for ENKTL patients treated with asparaginase-based regimens.
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참고문헌 (27)
참고문헌 신청
Yang QP / 2011 / Subtype distribution of lymphomas in Southwest China : analysis of 6, 382 cases using WHO classification in a single institution / Diagn Pathol 6:77
Xu W / 2014 / Distribution of lymphomas subtypes in Jiangsu Province : a multicenter analysis of 5 147 cases / Zhonghua Xue Ye Xue Za Zhi 35:300~303
Au WY / 2009 / Clinical differences between nasal and extranasal natural killer/T-cell lymphoma : a study of 136cases from the International Peripheral T-Cell Lymphoma Project / Blood 113:3931~3937
Perry AM / 2016 / Non-Hodgkin lymphoma in the Far East : review of 730 cases from the international non-Hodgkin lymphoma classification project / Ann Hematol 95:245~251
Lee J / 2006 / Extranodal natural killer T-cell lymphoma, nasal-type : a prognostic model from a retrospective multicenter study / J Clin Oncol 24:612~618
Xu W / 2014 / Distribution of lymphomas subtypes in Jiangsu Province : a multicenter analysis of 5 147 cases / Zhonghua Xue Ye Xue Za Zhi 35:300~303
Au WY / 2009 / Clinical differences between nasal and extranasal natural killer/T-cell lymphoma : a study of 136cases from the International Peripheral T-Cell Lymphoma Project / Blood 113:3931~3937
Perry AM / 2016 / Non-Hodgkin lymphoma in the Far East : review of 730 cases from the international non-Hodgkin lymphoma classification project / Ann Hematol 95:245~251
Lee J / 2006 / Extranodal natural killer T-cell lymphoma, nasal-type : a prognostic model from a retrospective multicenter study / J Clin Oncol 24:612~618
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