지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: Laser therapy can be used as an alternative treatment for onychomycosis; however, there are some limitations to its efficacy as a single agent. Objective: To evaluate the effectiveness of combination therapy with 1,064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser and topical efinaconazole in onychomycosis treatment and identify factors influencing the therapeutic outcomes of combination treatment. Methods: Big toenails with onychomycosis were treated by 1,064-nm Nd:YAG laser at 4-week intervals with daily application of topical efinaconazole. Therapeutic response was assessed through onychomycosis severity index (OSI) and percentage of nail infected (PNI), and its association with a variety of factors that may affect treatment outcome was evaluated. Results: One hundred big toenails were included in the study and significant clinical improvements were observed after treatment (OSI improvement score = 76.68 ± 28.83, PNI improvement score = 72.37 ± 30.37). There was no difference in treatment response according to the number of laser treatments, onychomycosis clinical type, or initial severity. However, patient age was negatively correlated with clinical improvement (p = 0.019). Also, female patients had better therapeutic responses than male patients. Conclusion: Combined treatment with Nd:YAG laser and topical efinaconazole has a significant therapeutic effect on onychomycosis. A randomized controlled trial is warranted in the future.
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참고문헌 (18)
참고문헌 신청
박진 / 2018 / Korean Guideline for the Diagnosis and Treatment of Onychomycosis: Purpose and Process of Algorithm Guideline Development / Journal of Mycology and Infection 23(2):33~44
Kim TI / 2016 / A randomised comparative study of 1,064 nm Neodymiumdoped yttrium aluminum garnet (Nd:YAG) laser and topical antifungal treatment of onychomycosis / Mycoses 59:803~810
Gupta AK / 2015 / A retrospective chart review of the clinical efficacy of Nd:YAG 1,064-nm laser for toenail onychomycosis / J Dermatolog Treat 26:376~378
Wanitphakdeedecha R / 2016 / Efficacy and safety of 1,064-nm Nd:YAG laser in treatment of onychomycosis / J Dermatolog Treat 27:75~79
Kim MS / 2016 / The effectiveness of 1,064-nm long-pulsed Nd:YAG laser in the treatment of severe onychomycosis / J Cosmet Laser Ther 18:317~322
Kim TI / 2016 / A randomised comparative study of 1,064 nm Neodymiumdoped yttrium aluminum garnet (Nd:YAG) laser and topical antifungal treatment of onychomycosis / Mycoses 59:803~810
Gupta AK / 2015 / A retrospective chart review of the clinical efficacy of Nd:YAG 1,064-nm laser for toenail onychomycosis / J Dermatolog Treat 26:376~378
Wanitphakdeedecha R / 2016 / Efficacy and safety of 1,064-nm Nd:YAG laser in treatment of onychomycosis / J Dermatolog Treat 27:75~79
Kim MS / 2016 / The effectiveness of 1,064-nm long-pulsed Nd:YAG laser in the treatment of severe onychomycosis / J Cosmet Laser Ther 18:317~322
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