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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제22권 제6호
- 발행연도
- 2019.1
- 수록면
- 501 - 510 (10page)
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초록· 키워드
오류제보하기
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. The global prevalence of pediatric NAFLD from general populations is 7.6%. In obese children, the prevalence is higher in Asia. NAFLD has a strong heritable component based on ethnic difference in the prevalence and clustering within families. Genetic polymorphisms of patatin-like phospholipase domain–containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2, and glucokinase regulatory protein (GCKR) are associated with the risk of NAFLD in children. Variants of PNPLA3 and GCKR are more common in Asians. Alterations of the gut microbiome might contribute to the pathogenesis of NAFLD. High fructose intake increases the risk of NAFLD. Liver fibrosis is a poor prognostic factor for disease progression to cirrhosis. Magnetic resonance spectroscopy and magnetic resonance proton density fat fraction are more accurate for steatosis quantification than ultrasound. Noninvasive imaging methods to assess liver fibrosis, such as transient elastography, shear-wave elastography, and magnetic resonance elastography are useful in predicting advanced fibrosis, but they need further validation. Longitudinal follow-up studies into adulthood are needed to better understand the natural history of pediatric NAFLD.
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등록된 정보가 없습니다.
참고문헌 (68)
참고문헌 신청
Adams LA / 2005 / The natural history of nonalcoholic fatty liver disease : a population-based cohort study / Gastroenterology 129:113~121
Anderson EL / 2015 / The prevalence of non-alcoholic fatty liver disease in children and adolescents : a systematic review and meta-analysis / PLoS One 10:e0140908
Kim JW / 2018 / Prevalence and risk factors of elevated alanine aminotransferase among Korean adolescents: 2001-2014 / BMC Public Health 18:617
Young Hoon Cho / 2019 / Association Between Vitamin D Deficiency and Suspected Nonalcoholic Fatty Liver Disease in an Adolescent Populatio / Pediatric Gastroenterology, Hepatology & Nutrition 22(3):233~241
Schwimmer JB / 2006 / Prevalence of fatty liver in children and adolescents / Pediatrics 118:1388~1393
Anderson EL / 2015 / The prevalence of non-alcoholic fatty liver disease in children and adolescents : a systematic review and meta-analysis / PLoS One 10:e0140908
Kim JW / 2018 / Prevalence and risk factors of elevated alanine aminotransferase among Korean adolescents: 2001-2014 / BMC Public Health 18:617
Young Hoon Cho / 2019 / Association Between Vitamin D Deficiency and Suspected Nonalcoholic Fatty Liver Disease in an Adolescent Populatio / Pediatric Gastroenterology, Hepatology & Nutrition 22(3):233~241
Schwimmer JB / 2006 / Prevalence of fatty liver in children and adolescents / Pediatrics 118:1388~1393
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