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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 42 - 50 (9page)
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Lysophosphatidic acid (LPA) is a lipid messenger mediated by G protein-coupled receptors (LPAR1-6). It is involved in the pathogenesis of certain chronic inflammatory and autoimmune diseases. In addition, it controls the self-renewal and differentiation of stem cells. Recent research has demonstrated the close relationship between periodontitis and various diseases in the human body. However, the precise role of LPA in the development of periodontitis has not been studied. We identified that LPAR1 was highly expressed in human periodontal ligament stem cells (PDLSCs). In periodontitis-mimicking conditions with Porphyromonas gingivalis -derived lipopolysaccharide (Pg-LPS) treatment, PDLSCs exhibited a considerable reduction in the cellular viability and osteogenic differentiation potential, in addition to an increase in the inflammatory responses including tumor necrosis factor-α and interleukin-1β expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. Of the various LPAR antagonists, pre-treatment with AM095, an LPAR1 inhibitor, showed a positive effect on the restoration of cellular viability and osteogenic differentiation, accompanied by a decrease in NF-κB signaling, and action against Pg-LPS. These findings suggest that the modulation of LPAR1 activity will assist in checking the progression of periodontitis and in its treatment.
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참고문헌 (19)
참고문헌 신청
George Hajishengallis / 2015 / Periodontitis: from microbial immune subversion to systemic inflammation / Nature Reviews Immunology 15(1):30~44
Paul T. Sharpe / 2016 / Dental mesenchymal stem cells / Development 143(13):2273~2280
Junjun Liu / 2015 / Concise Reviews: Characteristics and Potential Applications of Human Dental Tissue-Derived Mesenchymal Stem Cells / STEM CELLS 33(3):627~638
Danijela Menicanin / 2014 / Periodontal-Ligament-Derived Stem Cells Exhibit the Capacity for Long-Term Survival, Self-Renewal, and Regeneration of Multiple Tissue Types in Vivo / Stem Cells and Development 23(9):1001~1011
Zhu W / 2015 / Periodontal ligament stem cells: current status, concerns, and future prospects / Stem Cells Int 2015:972313
Paul T. Sharpe / 2016 / Dental mesenchymal stem cells / Development 143(13):2273~2280
Junjun Liu / 2015 / Concise Reviews: Characteristics and Potential Applications of Human Dental Tissue-Derived Mesenchymal Stem Cells / STEM CELLS 33(3):627~638
Danijela Menicanin / 2014 / Periodontal-Ligament-Derived Stem Cells Exhibit the Capacity for Long-Term Survival, Self-Renewal, and Regeneration of Multiple Tissue Types in Vivo / Stem Cells and Development 23(9):1001~1011
Zhu W / 2015 / Periodontal ligament stem cells: current status, concerns, and future prospects / Stem Cells Int 2015:972313
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Porphyromonas gingivalis Lipopolysaccharide Regulates Migration of Vascular Smooth Muscle Cells
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Effects of adjacent periodontitis on osseointegrated dental implants
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Avidity of serum immunoglobulin G antibodies to Porphyromonas gingivalis in the elderly with chronic periodontitis
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Effect of Cold Atmospheric Plasma on the erradication of Porphyromonas Gingivalis Biofilm for Periodontitis treatment
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