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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 603 - 607 (5page)
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Objective We aimed to compare cerebral beta-amyloid protein (Aβ) positivity rate and amyloid accumulation pattern on amyloid positron emission tomography (PET) between mild cognitive impairment (MCI) subtypes, i.e. amnestic mild cognitive impairment (aMCI) and non-amnestic mild cognitive impairment (naMCI).Methods The study participants were 34 naMCI patients and age-, sex- and education-matched 68 aMCI patients (1:2 ratio) who visited the Dementia and Age-Associated Cognitive Decline Clinic of the Seoul National University Hospital. All participants received comprehensive clinical and neuropsychological assessments and [<sup>18</sup>F] florbetaben PET.Results Aβ positivity rate of naMCI group (26.5%) was significantly lower than that of aMCI group (64.7%). Among Aβ positive individuals, there was no difference in Aβ accumulation pattern between naMCI and aMCI.Conclusion The findings suggest that MCI subtypes based on impaired cognitive domains have a differential association with brain Aβ deposition, a core pathology of AD. Amnestic subtype of MCI are more closely associated with cerebral Aβ deposition compared to nonamnestic subtype. In contrast, the pattern of amyloid deposition does not appear to have any difference between the subtypes.
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참고문헌 (20)
참고문헌 신청
Winblad B / 2004 / Mild cognitive impairment–beyond controversies, towards a consensus : report of the International Working Group on Mild Cognitive Impairment / J Intern Med 256:240~246
Petersen RC / 2005 / Mild cognitive impairment as a clinical entity and treatment target / Arch Neurol 62:1160~1163
Gauthier S / 2006 / Mild cognitive impairment / Lancet 367:1262~1270
Petersen RC / 2016 / Mild cognitive impairment / Continuum(Minneap Minn) 22:404~418
Roberts R / 2013 / Classification and epidemiology of MCI / Clin Geriatr Med 29:753~772
Petersen RC / 2005 / Mild cognitive impairment as a clinical entity and treatment target / Arch Neurol 62:1160~1163
Gauthier S / 2006 / Mild cognitive impairment / Lancet 367:1262~1270
Petersen RC / 2016 / Mild cognitive impairment / Continuum(Minneap Minn) 22:404~418
Roberts R / 2013 / Classification and epidemiology of MCI / Clin Geriatr Med 29:753~772
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