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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제3호
- 발행연도
- 2020.1
- 수록면
- 223 - 232 (10page)
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Sesamin, a lipid-soluble lignin originally isolated from sesame seeds, which induces cancer cell apoptosis and autophagy. In the present study, has been reported that sesamin induces apoptosis via several pathways in human lung cancer cells. However, whether mitophagy is involved in sesamin induced lung cancer cell apotosis remains unclear. This study, the anticancer activity of sesamin in lung cancer was studied by reactive oxygen species (ROS) and mitophagy. A549 cells were treated with sesamin, and cell viability, migration ability, and cell cycle were assessed using the CCK8 assay, scratch-wound test, and flow cytometry, respectively. ROS levels, mitochondrial membrane potential, and apoptosis were examined by flow cytometric detection of DCFH-DA fluorescence and by using JC-1 and TUNEL assays. The results indicated that sesamin treatment inhibited the cell viability and migration ability of A549 cells and induced G0/G1 phase arrest. Furthermore, sesamin induced an increase in ROS levels, a reduction in mitochondrial membrane potential, and apoptosis accompanied by an increase in cleaved caspase-3 and cleaved caspase-9. Additionally, sesamin triggered mitophagy and increased the expression of PINK1 and translocation of Parkin from the cytoplasm to the mitochondria. However, the antioxidant N-acetyl-L-cysteine clearly reduced the oxidative stress and mitophagy induced by sesamin. Furthermore, we found that cyclosporine A (an inhibitor of mitophagy) decreased the inhibitory effect of sesamin on A549 cell viability. Collectively, our data indicate that sesamin exerts lethal effects on lung cancer cells through the induction of ROS-mediated mitophagy and mitochondrial apoptosis.
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참고문헌 (36)
참고문헌 신청
Ferlay J / 2010 / Estimates of worldwide burden of cancer in 2008 : GLOBOCAN 2008 / Int J Cancer 127:2893~2917
Wakelee H / 2014 / 50 Years of progress in the systemic therapy of non-small cell lung cancer / Am Soc Clin Oncol Educ Book :177~189
Majdalawieh AF / 2017 / A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds(Sesamum indicum) / Eur J Pharmacol 815:512~521
Xu P / 2015 / Sesamin inhibits lipopolysaccharideinduced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells / Oncol Rep 33:3117~3123
Siao AC / 2015 / Effect of sesamin on apoptosis and cell cycle arrest in human breast cancer mcf-7 cells / Asian Pac J Cancer Prev 16:3779~3783
Wakelee H / 2014 / 50 Years of progress in the systemic therapy of non-small cell lung cancer / Am Soc Clin Oncol Educ Book :177~189
Majdalawieh AF / 2017 / A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds(Sesamum indicum) / Eur J Pharmacol 815:512~521
Xu P / 2015 / Sesamin inhibits lipopolysaccharideinduced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells / Oncol Rep 33:3117~3123
Siao AC / 2015 / Effect of sesamin on apoptosis and cell cycle arrest in human breast cancer mcf-7 cells / Asian Pac J Cancer Prev 16:3779~3783
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