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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 100 - 107 (8page)
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이 논문의 연구 히스토리 (3)
2018
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Objectives : The purpose of this study is to evaluate the anti-lipogenic effect of Sobuncheong-eum on non-alcoholic fatty liver disease in free fatty acid induced cellular model. Methods : HepG2 cells were treated with palmitate for 24h to overload intracellular triglyceride (TG) content in the presence or absence of Sobuncheong-eum extract. After palmitate treatment, Intracellular TG content was measured with TG assay kit. Several lipogenesis related markers, including AMP-activated protein kinase (AMPK), sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS), were assessed using Western-blot analyses and RT-PCR. Results : Palmitate markedly increased intracellular TG in HepG2 cells, and which were alleviated by coadministered Sobuncheong-eum extract. Sobuncheong-eum extract activated AMPK, which plays a key role in reducing hepatic lipid accumulation, and reduced lipogenic fators, SREBP-1c, ACC, and FAS. Conclusions : Taken together, it is conceivable that Sobuncheong-eum has an potential to alleviate steatosis, and which may be mediated by activating AMPK at least in part.
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참고문헌 (16)
참고문헌 신청
Chalasani N / 2012 / The diagnosis and management of non-alcoholic fatty liver disease : practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association / Hepatology 55(6):2005~2023
Angulo P. / 2005 / Nonalcoholic fatty liver disease / Revista de gastroenterologia de Mexico 70(Suppl 3):52~56
Matteoni CA / 1999 / Nonalcoholic fatty liver disease : a spectrum of clinical and pathological severity / Gastroenterology 116(6):1413~1419
Argo CK / 2009 / Epidemiology and natural history of non-alcoholic steatohepatitis / Clinics in liver disease 13(4):511~531
Popov VB / 2015 / Treatment of Nonalcoholic Fatty Liver Disease : The Role of Medical, Surgical, and Endoscopic Weight Loss / Journal of clinical and translational hepatology 3(3):230~238
Angulo P. / 2005 / Nonalcoholic fatty liver disease / Revista de gastroenterologia de Mexico 70(Suppl 3):52~56
Matteoni CA / 1999 / Nonalcoholic fatty liver disease : a spectrum of clinical and pathological severity / Gastroenterology 116(6):1413~1419
Argo CK / 2009 / Epidemiology and natural history of non-alcoholic steatohepatitis / Clinics in liver disease 13(4):511~531
Popov VB / 2015 / Treatment of Nonalcoholic Fatty Liver Disease : The Role of Medical, Surgical, and Endoscopic Weight Loss / Journal of clinical and translational hepatology 3(3):230~238
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