지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
To determine the regulatory roles of PDE4 inhibitor on LPS-induced osteoclastogenesis, we investigated the effect of a PDE4 inhibitor on osteoclast formation in the presence of LPS. A specific PDE4 inhibitor, rolipram, increased LPS-induced osteoclast formation in cocultures. To verify that whether rolipram acts indirectly on osteoblasts, we investigated the TRANCE and COX-2 mRNA expression levels in osteoblasts. Treatment of rolipram increased the expression of TRANCE and COX-2 mRNA in osteoblasts stimulated by LPS. On the contrary, rolipram did not augment the number of osteoclasts differentiated from bone marrow cells by LPS. In conclusion, the stimulation of LPS-induced osteoclast formation by the PDE4 inhibitor are attributable to its indirect effect on osteoblasts, not to their direct effect on bone marrow-derived osteoclast precursors.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Takahashi, N. / 1988 / Osteoblastic cells are involved in osteoclast formation / Endocrinology 123:2600
Suda, T. / 1999 / Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families / Endocr. Rev 20:345
Wong, B. R. / 1997 / TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun Nterminal kinase in T cells / J. Biol. Chem 272:25190
Yasuda, H / 1998 / Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesisinhibitory factor and is identical to TRANCE/RANKL / Proc. Natl. Acad. Sci. USA 95:3597
Lacey, D. L. / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93:165
Suda, T. / 1999 / Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families / Endocr. Rev 20:345
Wong, B. R. / 1997 / TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun Nterminal kinase in T cells / J. Biol. Chem 272:25190
Yasuda, H / 1998 / Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesisinhibitory factor and is identical to TRANCE/RANKL / Proc. Natl. Acad. Sci. USA 95:3597
Lacey, D. L. / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93:165
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