Morin, a Flavonoid from Moraceae, Inhibits Cancer Cell Adhesion to Endothelial Cells and EMT by Down-regulating VCAM-1 and N-cadherin

Lee, Jeong-Hee; Jin, Hana; Lee, Won Sup; Nagappan, Arulkumar; Choi, Yung Hyun; Kim, GonSup; Jung, Jin-Myung; Ryu, Chung Ho; Shin, Sung Chul; Hong, SoonChan; Kim, Hye Jung

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자료유형: 학술저널

저자정보: Lee, Jeong-Hee (Department of Pathology, Institute of Health Sciences) Jin, Hana (Department of Pharmacology, Institute of Health Sciences) Lee, Won Sup (Department of Internal Medicine, Institute of Health Sciences) Nagappan, Arulkumar (Department of Internal Medicine, Institute of Health Sciences) Choi, Yung Hyun (Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control [BK21 program], Dongeui University Graduate School) Kim, GonSup (School of Veterinary Medicine, Gyeongsang National University School of Medicine) Jung, Jin-Myung (Department of Neurosurgery, Institute of Health Sciences) Ryu, Chung Ho (Division of Applied Life Science [BK 21 Program], Institute of Agriculture and Life Science, Gyeongsang National University) Shin, Sung Chul (Department of Chemistry, and Research Institute of Life Science, Gyeongsang National University School of Medicine) Hong, SoonChan (Department of Surgery, Institute of Health Sciences) Kim, Hye Jung (Department of Pharmacology, Institute of Health Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제7호

발행연도: 2016.1

수록면: 3,071 - 3,075 (5page)

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Morin, a flavonoid found in figs and other Moraceae species, displays a variety of biological actions, exerting anti-oxidant, anti-inflammatory and anti-carcinogenic effects. Here, we investigated the anti-cancer activity of morin focusing on anti-adhesive influence. We performed experiments with MDA-MB-231 human breast cancer cells. Morin inhibited TNF-induced cancer cell adhesion to human umbilical vein endothelial cells (HUVECs) without showing any toxicity. It further inhibited the expression of VCAM-1 on MDA-MB-231 cells as well as HUVECs. Morin also decreased the expression of N-cadherin on MDA-MB-231 cells. In addition, there was apparent anti-metastatic activity in vivo. In conclusion, this study suggested that morin inhibits cancer cell adhesion to HUVECs by reducing VCAM-1, and EMT by targeting N-cadherin, and that it features anti-metastatic activity in vivo. Further investigation of possible anti-metastatic activity of morin against human breast cancer cells is warranted.

#Breast cancer cells #morin #metastasis #adhesion #VCAM-1 #N-cadherinn #downregulation

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