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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 40 - 44 (5page)
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초록· 키워드
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DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. In particular, chromatin opening is tightly coupled with gene transcription. To understand how these two processes are genetically regulated and associated with each other, we examined the changes of chromatin accessibility and gene expression in response to genetic variation by means of quantitative trait loci mapping. Regulatory patterns commonly observed in yeast and human across different technical platforms and experimental designs suggest a higher genetic complexity of transcription regulation in contrast to a more robust genetic architecture of chromatin regulation.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Brem RB. / 2002 / Genetic dissection of transcriptional regulation in budding yeast / Science 296:752~755
Brem RB. / 2005 / Genetic interactions between polymorphisms that affect gene expression in yeast / Nature 436:701~703
Cheung VG. / 2005 / Mapping determinants of human gene expression by regional and genome-wide association / Nature 437:1365~1369
Morley M. / 2004 / Genetic analysis of genome-wide variation in human gene expression / Nature 430:743~747
Pickrell JK. / 2010 / Understanding mechanisms underlying human gene expression variation with RNA sequencing / Nature 464:768~772
Brem RB. / 2005 / Genetic interactions between polymorphisms that affect gene expression in yeast / Nature 436:701~703
Cheung VG. / 2005 / Mapping determinants of human gene expression by regional and genome-wide association / Nature 437:1365~1369
Morley M. / 2004 / Genetic analysis of genome-wide variation in human gene expression / Nature 430:743~747
Pickrell JK. / 2010 / Understanding mechanisms underlying human gene expression variation with RNA sequencing / Nature 464:768~772
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