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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 225 - 232 (8page)
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We identified a novel Akt signaling mechanism that mediates fucoidan-induced suppression of human colon cancer cell (HT29) proliferation and anticancer effects. Fucoidan treatment significantly inhibited growth, induced G1-phase-associated upregulation of p21WAF1 expression, and suppressed cyclin and cyclin-dependent kinase expression in HT29 colon cancer cells. Additionally, fucoidan treatment activated the Akt signaling pathway, which was inhibited by treatment with an Akt inhibitor. The inhibition of Akt activation reversed the fucoidan-induced decrease in cell proliferation, the induction of G1-phase-associated p21WAF1 expression, and the reduction in cell cycle regulatory protein expression. Intraperitoneal injection of fucoidan reduced tumor volume; this enhanced antitumor efficacy was associated with induction of apoptosis and decreased angiogenesis. These data suggest that the activation of Akt signaling is involved in the growth inhibition of colon cancer cells treated with fucoidan. Thus, fucoidan may serve as a potential therapeutic agent for colon cancer.
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참고문헌 (26)
참고문헌 신청
Ahn, G. / 2008 / Immunomodulatory effects of an enzymatic extract from Ecklonia cava on murine splenocytes / Mar. Biotechnol. (NY) 10:278~289
Aisa, Y. / 2005 / Fucoidan induces apoptosis of human HSsultan cells accompanied by activation of caspase-3 and downregulation of ERK pathways / Am. J. Hematol 78:7~14
Boo, H. J. / 2011 / Fucoidan from Undaria pinnatifida induces apoptosis in A549 human lung carcinoma cells / Phytother. Res 25:1082~1086
Brett, C. M. / 1993 / Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney / Pharm. Res 10:423~426
Chen, L. C. / 2013 / P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo / J. Agric. Food Chem 61:2811~2819
Aisa, Y. / 2005 / Fucoidan induces apoptosis of human HSsultan cells accompanied by activation of caspase-3 and downregulation of ERK pathways / Am. J. Hematol 78:7~14
Boo, H. J. / 2011 / Fucoidan from Undaria pinnatifida induces apoptosis in A549 human lung carcinoma cells / Phytother. Res 25:1082~1086
Brett, C. M. / 1993 / Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney / Pharm. Res 10:423~426
Chen, L. C. / 2013 / P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo / J. Agric. Food Chem 61:2811~2819
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