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학술저널
저자정보
Bae, Bong Kyung (Department of Radiation Oncology, Kyungpook National University School of Medicine) Kang, Min Kyu (Department of Radiation Oncology, Kyungpook National University School of Medicine) Kim, Jae-Chul (Department of Radiation Oncology, Kyungpook National University School of Medicine) Kim, Mi Young (Department of Radiation Oncology, Kyungpook National University Chilgok Hospital) Choi, Gyu-Seog (Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine) Kim, Jong Gwang (Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine) Kang, Byung Woog (Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine) Kim, Hye Jin (Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine) Park, Soo Yeun (Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine)
저널정보
대한방사선종양학회 Radiation oncology journal : ROJ Radiation oncology journal : ROJ 제35권 제3호
발행연도
2017.1
수록면
208 - 216 (9page)

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Purpose: To evaluate the feasibility of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) for preoperative concurrent chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC), by comparing with 3-dimensional conformal radiotherapy (3D-CRT). Materials and Methods: Patients who were treated with PCRT for LARC from 2015 January to 2016 December were retrospectively enrolled. Total doses of 45 Gy to 50.4 Gy with 3D-CRT or SIB-IMRT were administered concomitantly with 5-fluorouracil plus leucovorin or capecitabine. Surgery was performed 8 weeks after PCRT. Between PCRT and surgery, one cycle of additional chemotherapy was administered. Pathologic tumor responses were compared between SIB-IMRT and 3D-CRT groups. Acute gastrointestinal, genitourinary, hematologic, and skin toxicities were compared between the two groups based on the RTOG toxicity criteria. Results: SIB-IMRT was used in 53 patients, and 3D-CRT in 41 patients. After PCRT, no significant differences were noted in tumor responses, pathologic complete response (9% vs. 7%; p = 1.000), pathologic tumor regression Grade 3 or higher (85% vs. 71%; p = 0.096), and R0 resection (87% vs. 85%; p = 0.843). Grade 2 genitourinary toxicities were significantly lesser in the SIB-IMRT group (8% vs. 24%; p = 0.023), but gastrointestinal toxicities were not different across the two groups. Conclusion: SIB-IMRT showed lower GU toxicity and similar tumor responses when compared with 3D-CRT in PCRT for LARC.

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