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자료유형
학술저널
저자정보
Gao, Song (Department of Obstetric and Gynecology, Shengjing Hospital of China Medical University) Liu, Ning (Department of Obstetric and Gynecology, Shengjing Hospital of China Medical University) Ma, Yang (Department of Obstetric and Gynecology, Shengjing Hospital of China Medical University) Ying, Liu (Department of Obstetrics and Gynecology, The Second West China Hospital, Sichuan University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제2호
발행연도
2012.1
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569 - 573 (5page)

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Early diagnosis and better prognosis of ovarian cancer is still a challenge. Besides environmental risk factors, genetic factors have established a role in pathogenesis of ovarian cancer. Methods: A case-control and a prospective study design conducted in 224 ovarian cancer patients and 432 controls in Chinese population. MTHFR C677T genotyping was done by PCR-RFLP. Results: Patients with ovarian cancer is associated with a higher less number of delivery and less frequent oral contraceptive use. When potential confounding factors adjusted logistic regression analysis between cases and controls were performed, significant association was obtained for 677T/T genotype and ovarian cancer (OR=3.13, 95% CI=1.59-5.72). Cox regression survival analysis showed individuals carrying T/T genotype had significantly increased HR for death in ovarian cancer patients (HR=2.86, 95% CI=1.27-7.93). In conclusion, we observed that the MTHFR C677T polymorphism is associated with the susceptibility and survival of ovarian cancer in Chinese population.

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