Tumor Necrosis Factor-α Gene Polymorphisms and Risk of Oral Cancer: Evidence from a Meta-analysis

Chen, Fang-Chun; Zhang, Fan; Zhang, Zhi-Jiao; Meng, Si-Ying; Wang, Yang; Xiang, Xue-Rong; Wang, Chun; Tang, Yu-Ying

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자료유형: 학술저널

저자정보: Chen, Fang-Chun (Department of Oral Medicine, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences) Zhang, Fan (School of Public Health and Health Management, Department of Foreign Language, Chongqing Medical University) Zhang, Zhi-Jiao (School of Public Health and Health Management, Department of Foreign Language, Chongqing Medical University) Meng, Si-Ying (Department of Foreign Language, Chongqing Medical University) Wang, Yang (School of Public Health and Health Management, Department of Foreign Language, Chongqing Medical University) Xiang, Xue-Rong (Department of Oral Medicine, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences) Wang, Chun (Department of Oral Medicine, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences) Tang, Yu-Ying (Department of Oral Medicine, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chon)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제12호

발행연도: 2013.1

수록면: 7,243 - 7,249 (7page)

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Numerous studies have been conducted regarding association between TNF-${\alpha}$ and oral cancer risk, but the results remain controversial. The present meta-analysis is performed to acquire a more precise estimation of relationships. Databases of Pubmed, the Cochrane library and the China National Knowledge Internet (CNKI) were retrieved until August 10, 2013. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with fixed- or random-effect models. The heterogeneity assumption was assessed by I-squared test. Among the eight included case-control studies, all were focused on TNF-${\alpha}$-308G>A and four also concerned the TNF-${\alpha}$-238G>A polymorphism. It was found that oral cancer risk were significant decreased with the TNF-${\alpha}$-308G>A polymorphism in the additive genetic model (GG vs. AA, OR=0.19, 95% CI: [0.04, 1.00], P=0.05, I2=68.9%) and the dominant genetic model (GG+GA vs. AA, OR=0.22, 95% CI: [0.06, 0.82], P=0.03, I2=52.4%); however, no significant association was observed in allele contrast (G vs. A, OR=0.70, 95% CI: [0.23, 2.16], P=0.54, I2=95.9%) and recessive genetic models (GG vs. GA+AA, OR=0.72, 95% CI: [0.33, 1.57], P=0.41, I2=93.1%). For the TNF-${\alpha}$-238G>A polymorphism, significant associations with oral cancer risk were found in the allele contrast (G vs. A, OR=2.75, 95% CI: [1.25, 6.04], P=0.01, I2=0.0%) and recessive genetic models (GG vs. GA+AA, OR=2.23, 95%CI: [1.18, 4.23], P=0.01, I2=0.0%). Conclusively, this meta-analysis indicates that TNF-${\alpha}$ polymorphisms may contribute to the risk of oral cancer. Allele G and the GG+GA genotype of TNF-${\alpha}$-308G>A may decrease the risk of oral cancer, while allele G and the GG genotype of TNF-${\alpha}$-238G>A may cause an increase.

#Tumor necrosis factor- ${alpha}$ #oral cancer #meta-analysis #polymorphism

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Chen, Fang-Chun

소속기관 Department of Oral Medicine, The Affiliated Hospital of Stomatology, Chongqing Medical University, C