The acute and sub-acute toxicity of C<sub>60</sub>/PVP complex in vivo

Dumpis, Marina A.; Iljin, Viktor V.; Litasova, Elena V.; Nikolaev, Dmitry N.; Bulion, Valentina V.; Krylova, Irina B.; Okunevich, Irina V.; Rodionova, Olga M.; Safonova, Albina F.; Selina, Elena N.; Piotrovsky, Levon B.

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저자정보: Dumpis, Marina A. (Department of Neuropharmacology, Institute of Experimental Medicine) Iljin, Viktor V. (Department of Neuropharmacology, Institute of Experimental Medicine) Litasova, Elena V. (Department of Neuropharmacology, Institute of Experimental Medicine) Nikolaev, Dmitry N. (Department of Neuropharmacology, Institute of Experimental Medicine) Bulion, Valentina V. (Department of Neuropharmacology, Institute of Experimental Medicine) Krylova, Irina B. (Department of Neuropharmacology, Institute of Experimental Medicine) Okunevich, Irina V. (Department of Neuropharmacology, Institute of Experimental Medicine) Rodionova, Olga M. (Department of Neuropharmacology, Institute of Experimental Medicine) Safonova, Albina F. (Department of Neuropharmacology, Institute of Experimental Medicine) Selina, Elena N. (Department of Neuropharmacology, Institute of Experimental Medicine) Piotrovsky, Levon B. (Department of Neuropharmacology, Institute of Experimental Medicine)

저널정보: 테크노프레스 Advances in nano research Advances in nano research 제4권 제3호

발행연도: 2016.1

수록면: 167 - 179 (13page)

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The detailed study of acute and sub-acute toxicity of the complex polyvinylpyrrolidon (PVP 20 kDa)-wrapped fullerene $C_{60}$ after intraperitoneal (ip) administration was carried out on adult male Wistar rats. The $LD_{50}$ value of $C_{60}/PVP$ complex was found to be 7, 8 g/kg. In sub-acute study which lasted for 30 days the rats were exposed to daily administration of the complex in the doses of 350 or 700 mg/kg. All animals survived during the study and had no significant changes in clinical signs, organ weight, hematological and biochemical parameters of blood. The electrophysiological properties of myocardium and the excretory function of kidneys remained normal. Histological analysis of liver, kidney and spleen at the end of the study also did not demonstrate toxic alterations. It was thus established that intraperitoneal administration of complex $C_{60}/PVP$ has no toxic effect. These results suggest that $C_{60}/PVP$ has no acute and sub-acute toxicity and is a perspective substance for potential application in biology and medicine.

#fullerene $C_{60}$ #polyvinylpyrrolidone #complex #toxicity

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