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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- (사)국제문화기술진흥원 The International journal of advanced culture technology The International journal of advanced culture technology 제6권 제4호
- 발행연도
- 2018.1
- 수록면
- 97 - 108 (12page)
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초록· 키워드
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The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and combination with herbal medicine on dextran sodium sulfate (DSS)-induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): group I-normal group, group II-DSS control group, group III-DSS + sulfasalazine (30 mg/kg), group IV-DSS + sulfasalazine (60 mg/kg), group V-DSS + sulfasalazine (30 mg/kg) + Radish Extract mixture (30 mg /kg) (SRE). DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. SRE supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SRE treatment significantly reduced the expression of pro-inflammatory signaling moleculesthrough suppression both mitogen-activated protein kinases(MAPK) and nuclear factor-kappa B ($NF-{\kappa}B$) signaling pathways, and prevented the apoptosis of colon. Moreover, SRE administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase. This is the first report that Radish extract mixture combined with sulfasalazine protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine.
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참고문헌 (17)
참고문헌 신청
정준석 / 2017 / Real-time Intelligent Exit Path Indicator Using BLE Beacon Enabled Emergency Exit Sign Controller / The International Journal of Advanced Smart Convergence 6(1):82~88
전형준 / 2017 / A Study on the Quality of Photometric Scanning Under Variable Illumination Conditions / The International Journal of Advanced Smart Convergence 6(4):88~95
김현경 / 2018 / Physiological Functionalities and Anti-oxidant activity of heated radish extract / The International Journal of Advanced Smart Convergence 7(2):38~46
K. Shailubhai / 2015 / Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis / World journal of gastrointestinal pharmacology and therapeutics 6(4):213~222
A. Kaser / 2010 / Inflammatory bowel disease / Annual review of immunology (28):573~621
전형준 / 2017 / A Study on the Quality of Photometric Scanning Under Variable Illumination Conditions / The International Journal of Advanced Smart Convergence 6(4):88~95
김현경 / 2018 / Physiological Functionalities and Anti-oxidant activity of heated radish extract / The International Journal of Advanced Smart Convergence 7(2):38~46
K. Shailubhai / 2015 / Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis / World journal of gastrointestinal pharmacology and therapeutics 6(4):213~222
A. Kaser / 2010 / Inflammatory bowel disease / Annual review of immunology (28):573~621
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