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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,168 - 1,178 (11page)
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초록· 키워드
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The present study aimed to characterise anti-oxidant peptides from water-soluble protein extracts of Hanwoo beef and evaluate their anti-proliferative effect on human colorectal carcinoma cells (HCT116). Antioxidant peptides were purified from the low-molecular-weight fraction (<3 kDa) of Hanwoo beef extract. Antioxidant activity of peptide fractions was determined using the oxygen radical absorbance capacity (ORAC) assay. Purified peptide (P3) displayed higher ORAC activity than the low-molecular-weight fraction ($202.66{\mu}M\;TE/g$ vs $167.38{\mu}M\;TE/g$ of dry matter, respectively) (p<0.05). The peptide sequence of P3 was Cys-Cys-Cys-Cys-Ser-Val-Gln-Lys (888.30 Da). The novel peptide P3, at $250{\mu}g/mL$, also significantly inhibited HCT116 cell proliferation up to 25.24% through phosphorylation of ERK, JNK, and p38 kinase (p<0.05). Hence, antioxidant peptide P3 from Hanwoo beef extract can be used as an antioxidative and anticancer agent in the functional food industry.
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등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Agarwal R / 2006 / Anticancer potential of silymarin: From bench to bed side / Anticancer Res 26:4457~4498
Ahmed-Choudhury J / 2006 / CD40 mediated human cholangiocyte apoptosis required JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2 / Cell Signal 18:456~468
Chang OK / 2013 / Casein hydrolysis by Bifidobacterium longum KACC91563 and antioxidant activities of peptides derived therefrom / J Dairy Sci 96:5544~5555
Choi Y / 2009 / Antioxidant and antiproliferative properties of a tocotrienol-rich fraction from grape seeds / Food Chem 114:1386~1390
Cross AJ / 2007 / A prospective study of red and processed meat intake in relation to cancer risk / PLOS Med 4:e325
Ahmed-Choudhury J / 2006 / CD40 mediated human cholangiocyte apoptosis required JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2 / Cell Signal 18:456~468
Chang OK / 2013 / Casein hydrolysis by Bifidobacterium longum KACC91563 and antioxidant activities of peptides derived therefrom / J Dairy Sci 96:5544~5555
Choi Y / 2009 / Antioxidant and antiproliferative properties of a tocotrienol-rich fraction from grape seeds / Food Chem 114:1386~1390
Cross AJ / 2007 / A prospective study of red and processed meat intake in relation to cancer risk / PLOS Med 4:e325
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