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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.25 No.4
- 발행연도
- 2020.12
- 수록면
- 353 - 361 (9page)
- DOI
- 10.3746/pnf.2020.25.4.353
이용수
초록· 키워드
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The aim of this study was to evaluate the impact of the green algae Ulva lactuca and its hydroethanolic extract on insulin resistance and cholesterol reverse transport in type 2 diabetic (T2D) rats. Rats had T2D induced by a high-fat diet (HFD) for 5 weeks followed by intraperitoneal injection of streptozotocin. Diabetic rats were divided into three groups and were fed a HFD in the presence or absence of 1% alga (HFD-Alg) or 1% of its hydroethanolic extract (HFD-Ext), for 4 weeks. The control group consumed 20% casein combined with 5% lipids. Hyperglycemia, insulin resistance, hypercholesterolemia, and hypertriglyceridemia were noted in HFD rats vs control rats. Whole alga and its extract decreased these parameters vs the HFD. Moreover, fecal total cholesterol and triacylglycerols levels were lowered in HFD group vs C group, but were increased with HFD-Alg vs HFD. Compared with the Control, the HFD group had decreased lecithin:cholesterol acyltransferase (LCAT) activity, apolipoprotein A-I (ApoA-I), high-density lipoprotein (HDL₃)-phospholipids (PL), and HDL₂-cholesteryl ester (CE) levels, but increased HDL₃-unesterified cholesterol (UC) levels. Furthermore, compared with the HFD group, the HFD-Alg and HFD-Ext groups had increased LCAT activity, ApoA-I, HDL₃-PL, and HDL2-CE levels and decreased HDL₃-UC levels. In addition, in the HFD-Ext group, LCAT activity and ApoA-1 levels were decreased vs the HFD-Alg whereas HDL₃-UC levels were increased. In conclusion, these results indicate that U. lactuca and its hydroethanolic extract have curative effect on T2D. Therefore, this alga could be considered a functional food supplement for the treatment and prevention of diabetes.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (57)
참고문헌 신청
Sameh Fekry AbouZid / 2014 / Antihyperglycemic Effect of Crude Extracts of Some Egyptian Plants and Algae / Journal of Medicinal Food 17(3):400~406
Acosta-Montaño P / 2018 / Effects of dietary fatty acids in pancreatic beta cell metabolism, implications in homeostasis / Nutrients 10:393
Akbarzadeh S / 2018 / Anti-diabetic effects of Sargassum oligocystum on streptozotocin-induced diabetic rat / Iran J Basic Med Sci 21:342~346
Albers JJ / 1986 / Isolation, characterization, and assay of lecithin-cholesterol acyltransferase / Methods Enzymol 129:763~783
Ashok Kumar N / 2018 / Ulva reticulata, a marine alga normalize streptozotocin induced lipid peroxidation in experimental diabetic rats / J Drug Deliv Ther 8:12~15
Acosta-Montaño P / 2018 / Effects of dietary fatty acids in pancreatic beta cell metabolism, implications in homeostasis / Nutrients 10:393
Akbarzadeh S / 2018 / Anti-diabetic effects of Sargassum oligocystum on streptozotocin-induced diabetic rat / Iran J Basic Med Sci 21:342~346
Albers JJ / 1986 / Isolation, characterization, and assay of lecithin-cholesterol acyltransferase / Methods Enzymol 129:763~783
Ashok Kumar N / 2018 / Ulva reticulata, a marine alga normalize streptozotocin induced lipid peroxidation in experimental diabetic rats / J Drug Deliv Ther 8:12~15
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