Beneficial effects of posttransplant dipeptidyl peptidase-4 inhibitor administration after pancreas transplantation to improve β cell function

Hye-Won Jang; Chang Hee Jung; Youngmin Ko; Seong Jun Lim; Hye Eun Kwon; Joo Hee Jung; Hyunwook Kwon; Young Hoon Kim; Sung Shin

추천

검색

질문

자료유형: 학술저널

저자정보: Hye-Won Jang (University of Ulsan College of Medicine) Chang Hee Jung (University of Ulsan College of Medicine) Youngmin Ko (University of Ulsan College of Medicine) Seong Jun Lim (University of Ulsan College of Medicine) Hye Eun Kwon (University of Ulsan College of Medicine) Joo Hee Jung (University of Ulsan College of Medicine) Hyunwook Kwon (University of Ulsan College of Medicine) Young Hoon Kim (University of Ulsan College of Medicine) Sung Shin (University of Ulsan College of Medicine)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.101 No.3

발행연도: 2021.9

수록면: 187 - 196 (10page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: Dipeptidyl peptidase-4 (DPP-4) inhibitors lower blood glucose levels and enhance the function of pancreatic β cells. Yet, it is unknown whether posttransplant administration of DPP4 inhibitors is beneficial for pancreas transplant recipients.
Methods: We thus retrospectively analyzed the records of 312 patients who underwent pancreas transplantation between 2000 and 2018 at Asan Medical Center (Seoul, Korea) and compared the metabolic and survival outcomes according to DPP-4 inhibitor treatment.
Results: The patients were divided into the no DPP-4 inhibitor group (n = 165; no treatment with DPP-4 inhibitors or treated for <1 month) and the DPP-4 inhibitor group (n = 147; treated with DPP-4 inhibitors for ≥1 month). There were no significant differences in levels of glucose, hemoglobin A1c, and insulin between the 2 groups during 36 months of follow-up. However, the level of C-peptide was significantly higher in the DPP-4 inhibitor group at 1, 6, and 24 months posttransplant (all P < 0.05). Moreover, the DPP-4 inhibitor group had significantly higher rates of overall (log-rank test, P = 0.009) and death-censored (log-rank test, P = 0.036) graft survival during a 15-year follow-up.
Conclusion: Posttransplant DPP-4 inhibitor administration may help improve the clinical outcomes including β cell function after pancreas transplantation.

#Beta cell function #Dipeptidyl peptidase-4 inhibitor #Insulin sensitivity #Pancreas transplantation

참고문헌 (2)

참고문헌 신청

Burke GW / 2004 / Advances in pancreas transplantation / Transplantation 77(9 Suppl):S62~S67

배은주 / 2016 / DPP-4 inhibitors in diabetic complications: role of DPP-4 beyond glucose control / Archives of Pharmacal Research 39(8):1114~1128

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!