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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 401 - 407 (7page)
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Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which is an ongoing pandemic disease. SARS-CoV-2- specific CD4+ and CD8+ T-cell responses have been detected and characterized not only in COVID-19 patients and convalescents, but also unexposed individuals. Here, we review the phenotypes and functions of SARS-CoV-2-specific T cells in COVID-19 patients and the relationships between SARS-CoV-2-specific T-cell responses and COVID-19 severity. In addition, we describe the phenotypes and functions of SARS-CoV-2-specific memory T cells after recovery from COVID-19 and discuss the presence of SARS-CoV-2-reactive T cells in unexposed individuals and SARS-CoV-2-specific T-cell responses elicited by COVID-19 vaccines. A better understanding of T-cell responses is important for effective control of the current COVID-19 pandemic.
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참고문헌 (63)
참고문헌 신청
Agerer, B. / 2021 / SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses / Sci. Immunol 6:eabg6461
Akondy, R. S. / 2017 / Origin and differentiation of human memory CD8 T cells after vaccination / Nature 552:362~367
Anderson, E. J. / 2020 / Safety and immunogenicity of SARS-CoV-2 mRNA-1273vaccine in older adults / N. Engl. J. Med 383:2427~2438
Bacher, P. / 2020 / Low-avidity CD4(+) T cell responses to SARS-CoV-2 in unexposed individuals and humans with severe COVID-19 / Immunity 53:1258~1271.e5
Bodewes, R. / 2009 / Yearly influenza vaccinations: a double-edged sword? / Lancet Infect. Dis 9:784~788
Akondy, R. S. / 2017 / Origin and differentiation of human memory CD8 T cells after vaccination / Nature 552:362~367
Anderson, E. J. / 2020 / Safety and immunogenicity of SARS-CoV-2 mRNA-1273vaccine in older adults / N. Engl. J. Med 383:2427~2438
Bacher, P. / 2020 / Low-avidity CD4(+) T cell responses to SARS-CoV-2 in unexposed individuals and humans with severe COVID-19 / Immunity 53:1258~1271.e5
Bodewes, R. / 2009 / Yearly influenza vaccinations: a double-edged sword? / Lancet Infect. Dis 9:784~788
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