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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제7호
- 발행연도
- 2020.1
- 수록면
- 967 - 973 (7page)
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초록· 키워드
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The fungal cell wall is a major target of antifungals. In this study, we report the antifungal activity of an ethanol extract from Aucklandia lappa against Candida albicans. We found that the extract caused cell wall injury by decreasing chitin synthesis or assembly and (1,3)-β-D-glucan synthesis. A sorbitol protection assay demonstrated that the minimum inhibitory concentration (MIC) of the A. lappa extract against C. albicans cells increased eight-fold from 0.78 to 6.24 mg/ml in 72 h. Cell aggregates, which indicate damage to the cell wall or membrane, were commonly observed in the A. lappatreated C. albicans cells through microscopic analysis. In addition, the relative fluorescence intensities of the C. albicans cells incubated with the A. lappa extract for 3, 5, and 6 h were 92.1, 84.6, and 79.8%, respectively, compared to the controls, estimated by Calcofluor White binding assay. This result indicates that chitin content was reduced by the A. lappa treatment. Furthermore, synthesis of (1,3)-β-D-glucan polymers was inhibited to 84.3, 79.7, and 70.2% of that of the control treatment following incubation of C. albicans microsomes with the A. lappa extract at a final concentration equal to its MIC, 2× MIC, and 4× MIC, respectively. These findings suggest that the A. lappa ethanol extract may aid the development of a new antifungal to successfully control Candidaassociated disease.
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참고문헌 (26)
참고문헌 신청
Krcmery V / 2002 / Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance / J. Hosp. Infect. 50:243~260
Hachem R / 2008 / The changing epidemiology of invasive candidiasis: Candida glabrata and Candida krusei as the leading causes of candidemia in hematologic malignancy / Cancer 112:2493~2499
Reyna-Beltrán E / 2019 / The cell wall of Candida albicans : A proteomics view / IntechOpen Chapter 4:71~92
Ruiz-Herrera J / 2010 / Analysis of the phylogenetic relationships and evolution of the cell walls from yeasts and fungi / FEMS Yeast Res 10:225~243
Ruiz-Herrera J / 2006 / Molecular organization of the cell wall of Candida albicans and its relation to pathogenicity / FEMS Yeast Res 6:14~29
Hachem R / 2008 / The changing epidemiology of invasive candidiasis: Candida glabrata and Candida krusei as the leading causes of candidemia in hematologic malignancy / Cancer 112:2493~2499
Reyna-Beltrán E / 2019 / The cell wall of Candida albicans : A proteomics view / IntechOpen Chapter 4:71~92
Ruiz-Herrera J / 2010 / Analysis of the phylogenetic relationships and evolution of the cell walls from yeasts and fungi / FEMS Yeast Res 10:225~243
Ruiz-Herrera J / 2006 / Molecular organization of the cell wall of Candida albicans and its relation to pathogenicity / FEMS Yeast Res 6:14~29
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