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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제10호
- 발행연도
- 2020.1
- 수록면
- 1,458 - 1,466 (9page)
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초록· 키워드
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Oligomeric proanthocyanidins (OPCs), classified as condensed tannins, have significant antioxidation, anti-inflammation and anti-cancer effects. This study was performed to investigate the anti-inflammatory effects of OPCs and the mechanism underlying these effects in lipopolysaccharide (LPS)-stimulated bovine mammary epithelial cells (MAC-T). Real-time PCR and ELISA assays indicated that OPC treatment at 1, 3 and 5 μg/ml significantly reduced the mRNA and protein, respectively, of oxidant indicators cyclooxygenase-2 (COX-2) (p < 0.05) and inducible nitric oxide synthase (iNOS) (p < 0.01) as well as inflammation cytokines interleukin (IL)-6 (p < 0.01), IL-1β (p < 0.01) and tumor necrosis factor-α (TNF-α) (p < 0.05) in LPS-induced MAC-T cells. Moreover, OPCs downregulated LPSinduced phosphorylation of p65 and inhibitor of nuclear factor kappa B (NF-κB) (IκB) in the NF-κB signaling pathway (p < 0.01), and they inhibited p65 translocation from the cytoplasm to the nucleus as revealed by immunofluorescence test and western blot. Additionally, OPCs decreased phosphorylation of p38, extracellular signal regulated kinase and c-jun NH2-terminal kinase in the MAPK signaling pathway (p < 0.01). In conclusion, the anti-inflammatory and antioxidant activities of OPCs involve NF-κB and MAPK signaling pathways, thus inhibiting expression of pro-inflammatory factors and oxidation indicators. These findings provide novel experimental evidence for the further practical application of OPCs in prevention and treatment of bovine mastitis.
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참고문헌 (41)
참고문헌 신청
Zhang XJ / 2019 / Progress on epigenetic regulation of the pathogenesis of cow mastitis / Chin. J. Anim. Sci 55:22~28
Chen XX / 2018 / Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NFκB signaling pathway / Inflamm. Res 67:903~911
Fu YH / 2014 / Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model / FEBS J 281:2543~2557
Hu XL / 2012 / Effects of trichostatin A on the expressions of inflammatory cytokines and Toll-like receptor 4 and the acetylation of nuclear factor-κB induced by lipopolysaccharide in macrophage / Acta Physiol. Sin 64:651~656
Nan B / 2020 / Acrylamide induced the activation of NLRP3 inflammasome via ROS-MAPKs pathways in Kupffer cells / Food Agric. Immunol 31:45~62
Chen XX / 2018 / Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NFκB signaling pathway / Inflamm. Res 67:903~911
Fu YH / 2014 / Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model / FEBS J 281:2543~2557
Hu XL / 2012 / Effects of trichostatin A on the expressions of inflammatory cytokines and Toll-like receptor 4 and the acetylation of nuclear factor-κB induced by lipopolysaccharide in macrophage / Acta Physiol. Sin 64:651~656
Nan B / 2020 / Acrylamide induced the activation of NLRP3 inflammasome via ROS-MAPKs pathways in Kupffer cells / Food Agric. Immunol 31:45~62
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