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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제1호
- 발행연도
- 2021.1
- 수록면
- 39 - 49 (11page)
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High fructose diet is associated with the global metabolic syndrome (MtS) pandemic. MtS develops in early life, depending on prenatal and postnatal nutritional status. We hypothesized that ovariectomy increases the chances of developing MtS in adult offspring following high fructose intake by the mother. Pregnant C57BL/6J mouse dams drank water with or without 20% fructose during pregnancy and lactation. After weaning, the pups were fed regular chow. The offspring were evaluated until they were 7 months of age after the mice in each group, both sexes, were gonadectomized at 4 weeks of age. The offspring (both sexes) of the dams who had high fructose intake developed MtS. In the offspring of dams who drank tap water, orchiectomy increased the body weight gain and body fat accumulation, while ovariectomy increased the body fat accumulation as compared to the sham controls. In the offspring of dams with high fructose intake, orchiectomy decreased the body weight gain, body fat accumulation, visceral adiposity, and glucose intolerance, while ovariectomy exacerbated all of them as compared to the sham operations. These data indicate that ovariectomy encourages the development of MtS in adult offspring after maternal high fructose intake, while orchiectomy prevents the development of MtS. The sex difference indicates that male and female sex hormones play contradictory roles in the development of MtS.
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등록된 정보가 없습니다.
참고문헌 (52)
참고문헌 신청
Bray GA / 2008 / Fructose: should we worry? / Int J Obes 32(Suppl 7):S127~S131
Tappy L / 2010 / Metabolic effects of fructose and the worldwide increase in obesity / Physiol Rev 90:23~46
Marriott BP / 2009 / National estimates of dietary fructose intake increased from 1977 to 2004 in the United States / J Nutr 139:1228S~1235S
Withrow D / 2011 / The economic burden of obesity worldwide : a systematic review of the direct costs of obesity / Obes Rev 12:131~141
Ferder L / 2010 / The role of high-fructose corn syrup in metabolic syndrome and hypertension / Curr Hypertens Rep 12:105~112
Tappy L / 2010 / Metabolic effects of fructose and the worldwide increase in obesity / Physiol Rev 90:23~46
Marriott BP / 2009 / National estimates of dietary fructose intake increased from 1977 to 2004 in the United States / J Nutr 139:1228S~1235S
Withrow D / 2011 / The economic burden of obesity worldwide : a systematic review of the direct costs of obesity / Obes Rev 12:131~141
Ferder L / 2010 / The role of high-fructose corn syrup in metabolic syndrome and hypertension / Curr Hypertens Rep 12:105~112
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