Development of a Korean Culture-Friendly Olfactory Function Test and Optimization of a Diagnostic Cutoff Value

하종균; 김진원; 남재성; 박정진; 조형주; 윤주헌; 김창훈

추천

검색

자료유형: 학술저널

저자정보: 하종균 (연세대학교) 김진원 (연세대학교 의과대학 이비인후과학교실) 남재성 (연세대학교) 박정진 (연세대학교) 조형주 (연세대학교) 윤주헌 (연세대학교) 김창훈 (연세대학교)

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제13권 제3호

발행연도: 2020.1

수록면: 274 - 284 (11page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objectives. Cultural familiarity and safety must be considered when assessing olfactory ability. The YSK olfactory function (YOF) test is a new olfactory function test using culturally familiar odorants to Koreans. Methods. The YOF test comprises three subtests for threshold (T), discrimination (D), and identification (I). The identification test included eight universal and four Korean culture-friendly odorants, which were selected considering eight major functional groups. Data were obtained from 1,127 subjects over 19 years old. Subjects were classified as having normosmia (n=542), hyposmia (n=472), and anosmia (n=113) by self-reported olfactory function. The YOF test and the Korean version of the Sniffin’ stick test (KVSS-II) were performed on the same day in random order. Diagnostic cutoffs for anosmia and hyposmia were calculated using the Youden index (J). Results. The mean values for each T/D/I subtest and the total TDI score were as follows: normosmia (T, 4.6±2.3; D, 8.6±2.1; I, 11.1±1.7; TDI score, 24.2±4.5); hyposmia (T, 3.3±2.2; D, 7.1±2.5; I, 9.2±3.1; TDI score, 19.5±6.4); and anosmia (T, 1.7±1.2; D, 5.1±2.5; I, 5.0±3.2; TDI score, 11.8±5.6). The correlation coefficients between the YOF test and KVSS-II were 0.57, 0.65, 0.80, and 0.86 for T, D, I, and the TDI score, respectively (P<0.001). The diagnostic cutoffs were a TDI score ≤14.5 (J=0.67) for anosmia and 14.5<TDI score ≤21.0 (J=0.38) for hyposmia. The diagnostic efficacy of the YOF test (area under the curve [AUC], 0.88) was equivalent to that of the KVSS-II (AUC, 0.88; P=0.843; DeLong method). Conclusion. The YOF test is a new olfactory test using safe and Korean culture-friendly odorants. It showed equivalent validity with the conventional olfactory function test. Furthermore, the YOF test provides information on the major functional groups of odorants, potentially enabling a more comprehensive interpretation for patients with olfactory disorders.

#Smell #Olfactory Perception #Culture #Odorants

참고문헌 (38)

참고문헌 신청

Blomqvist EH / 2004 / Consequences of olfactory loss and adopted coping strategies / Rhinology 42(4):189~194

Asahina K / 2008 / The survival advantage of olfaction in a competitive environment / Curr Biol 18(15):1153~1155

Berendse HW / 2006 / Detection of preclinical Parkinson’s disease along the olfactory trac(t) / J Neural Transm Suppl (70):321~325

Jung HJ / 2019 / Olfactory function in mild cognitive impairment and Alzheimer’s disease : a meta-analysis / Laryngoscope 129(2):362~369

Pause BM / 2001 / Reduced olfactory performance in patients with major depression / J Psychiatr Res 35(5):271~277

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!