지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 380 - 405 (26page)
이용수
초록· 키워드
오류제보하기
Ceramide and sphingomyelin (SM) are major components of the double membrane-bound sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes including apoptosis, necrosis, and autophagy-dependent cell death. Inversely, SM regulates opposite cellular processes such as proliferation and migration by changing receptor-mediated signal transduction in the lipid microdomain. SM is generated through a transfer of phosphocholine from phosphatidylcholine to ceramide by SM synthases (SMSs). Research during the past several decades has revealed that the ceramide/SM balance in cellular membranes regulated by SMSs is important to decide the cell fate, survival, and proliferation. In addition, recent experimental studies utilizing SMS knockout mice and murine disease models provide evidence that SMS-regulated ceramide/SM balance is involved in human diseases. Here, we review the basic structural and functional characteristics of SMSs and focus on their cellular functions through the regulation of ceramide/SM balance in membrane microdomains. In addition, we present the pathological or physiological implications of SMSs by analyzing their role in SMS-knockout mice and human disease models. This review finally presents evidence indicating that the regulation of ceramide/SM balance through SMS could be a therapeutic target for human disorders.
목차
등록된 정보가 없습니다.
참고문헌 (144)
참고문헌 신청
Hannun YA / 2008 / Principles of bioactive lipid signalling : lessons from sphingolipids / Nat Rev Mol Cell Biol 9:139~150
Hannun YA / 2018 / Sphingolipids and their metabolism in physiology and disease / Nat Rev Mol Cell Biol 19:175~191
Tafesse FG / 2006 / The multigenic sphingomyelin synthase family / J Biol Chem 281:29421~29425
Taniguchi M / 2014 / The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration-from cell and animal models to human disorders / Biochim Biophys Acta 1841:692~703
Simons K / 2000 / Lipid rafts and signal transduction / Nat Rev Mol Cell Biol 1:31~39
Hannun YA / 2018 / Sphingolipids and their metabolism in physiology and disease / Nat Rev Mol Cell Biol 19:175~191
Tafesse FG / 2006 / The multigenic sphingomyelin synthase family / J Biol Chem 281:29421~29425
Taniguchi M / 2014 / The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration-from cell and animal models to human disorders / Biochim Biophys Acta 1841:692~703
Simons K / 2000 / Lipid rafts and signal transduction / Nat Rev Mol Cell Biol 1:31~39
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Vitamin C Stimulates Epidermal Ceramide Production by Regulating Its Metabolic Enzymes
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Recent advances in diagnosis and therapy in systemic mastocytosis
Blood Research
2023 .04
-
Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth
Annals of Dermatology
2019 .01
-
Phytochemical Analysis and Wound Healing Potential of Ethanol Extract of Sea Mustard and Sea Mustard Sporophyll
대한의생명과학회지
2019 .12
-
Ceramides: Nutrient Signals that Drive Hepatosteatosis
지질·동맥경화학회지
2020 .01
-
Ceramide synthesis inhibition in the liver and kidney
대한체질인류학회 학술대회 연제 초록
2017 .06
-
고지방식이로 비만을 유도한 C57BL/6 마우스에서 SM17의 항산화 및 항비만 효과
대한본초학회지(본초분과학회지)
2017 .01
-
Recent advances in the formulation of sphingolipid anticancer therapeutics
Journal of Pharmaceutical Investigation
2020 .01
-
Genetic Architecture of Circulating Very-Long-Chain (C24:0 and C22:0) Ceramide Concentrations
지질·동맥경화학회지
2020 .01
-
The Complex Tail of Circulating Sphingolipids in Atherosclerosis and Cardiovascular Disease
지질·동맥경화학회지
2021 .09
-
Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats
Journal of Ginseng Research
2021 .09
-
Hepatic Expression of the Serine Palmitoyltransferase Subunit Sptlc2 Reduces Lipid Droplets in the Liver by Activating VLDL Secretion
지질·동맥경화학회지
2020 .01
-
Development and Validation of the Full Version of Story Memory in the Korean-Mini Mental State Examination, 2nd Edition: Expanded Version (K-MMSE-2: EV)
Dementia and Neurocognitive Disorders(대한치매학회지)
2019 .01
-
Use of social media in education among medical students in Saudi Arabia
Korean Journal of Medical Education
2016 .01
-
Development of a Label-Free LC-MS/MS-Based Glucosylceramide Synthase Assay and Its Application to Inhibitors Screening for Ceramide-Related Diseases
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Expression of ceramide synthase 5 in mouse retina
대한체질인류학회 학술대회 연제 초록
2021 .05
-
황련추출물-ceramide 복합물의 지방장벽 형성 조절을 통한 상피 염증 완화 효과
대한한방소아과학회지
2021 .08
-
단삼과 단삼음의 역류성 식도염 억제 효과 및 암세포 이주 억제 효과
대한한방내과학회지
2022 .12
-
SM-2015의 혈중 알코올 분해 및 숙취 개선 효과
대한한방내과학회지
2017 .01
-
A Normative Study of the Full Version of Story Memory in the Korean-Mini Mental State Examination, 2nd Edition: Expanded Version (K-MMSE-2: EV)
Dementia and Neurocognitive Disorders(대한치매학회지)
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0