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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.11 No.1
- 발행연도
- 2019.1
- 수록면
- 68 - 78 (11page)
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Purpose: Data comparing the long-term efficacy and safety of subcutaneous immunotherapy (SCIT) using house dust mite (HDM) in children and adults with allergic rhinitis (AR) are limited. This study aimed to compare the long-term effects of HDM-SCIT in a cohort of Chinese pediatric and adult patients with AR. Methods: A total of 124 pediatric and adult AR patients received HDM-SCIT for 3 years, with 118 patients being followed-up for 2 years. Prior to treatment (baseline), at the end of the 3-year treatment periods (third year) and 2 years after the discontinuation of treatment (fifth year), all patients were evaluated for total nasal symptom scores (TNSS), daily medication score (DMS), total combined score (TCS; symptoms [nasal + ocular] + DMS) and quality of life (QoL). Safety was assessed according to adverse events reported. Results: After 3-year treatment, HDM-SCIT significantly improved symptoms and QoL scores at the end of the third and fifth years in both groups. Better improvements were observed in the third and fifth years based on baseline, in children compared to adults (TNSSΔ3: 6.66 vs. 5.41, P = 0.011; TCSΔ3: 4.30 vs. 3.83, P = 0.027 and TNSSΔ5: 6.16 vs. 4.86, P = 0.037; TCSΔ5: 4.11 vs. 3.62, P = 0.044).Shorter duration of AR history before SCIT (<10 vs. ≥10 years) resulted in better improvements at the end of the third and fifth years (TCSΔ3: 4.12 vs. 3.13, P = 0.036; TCSΔ5: 3.90 vs. 3.09, P = 0.033). HDM-SCIT was safe and comparable in both children and adults with AR. Conclusions: Children with AR may achieve better long-term efficacy of HDM-SCIT than adults with AR.
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참고문헌 (19)
참고문헌 신청
Soh JY / 2016 / Sublingual immunotherapy in patients with house dust mite allergic rhinitis : prospective study of clinical outcomes over a two-year period / J Laryngol Otol 130:272~277
Lou H / 2017 / Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China / Sci Rep 7:9286
Bousquet J / 2008 / Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) / Allergy 2008;63 Suppl 63(Suppl 86):8~160
Baris S / 2014 / Vitamin D as an adjunct to subcutaneous allergen immunotherapy in asthmatic children sensitized to house dust mite / Allergy 69:246~253
Juniper EF / 1991 / Development and testing of a new measure of health status for clinical trials in rhinoconjunctivitis / Clin Exp Allergy 21:77~83
Lou H / 2017 / Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China / Sci Rep 7:9286
Bousquet J / 2008 / Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) / Allergy 2008;63 Suppl 63(Suppl 86):8~160
Baris S / 2014 / Vitamin D as an adjunct to subcutaneous allergen immunotherapy in asthmatic children sensitized to house dust mite / Allergy 69:246~253
Juniper EF / 1991 / Development and testing of a new measure of health status for clinical trials in rhinoconjunctivitis / Clin Exp Allergy 21:77~83
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