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저자정보
정성수 (부산대학교) So-Yeon Lee (University of Ulsan) Jisun Yoon (Mediplex Sejong Hospital) Hyun-Ju Cho (Catholic Kwandong University) Young-Ho Kim (University of Ulsan) Dong In Suh (Seoul National University) Song-I Yang (Hallym University) Ji-Won Kwon (Seoul National University) Gwang Cheon Jang (National Health Insurance Service) Yong Han Sun (Gachon University) Sung-Il Woo (Chungbuk National University) You-Sook Youn (The Catholic University of Korea) Kang-Seo Park (Presbyterian Medical Center) Eun Lee (Chonnam National University) Hwa Jin Cho (Chonnam National University) Myung-Hee Kook (Gwangju Veterans Hospital) Hye Ryoung Yi (Gwangju Veterans Hospital) Hai Lee Chung (Catholic University of Daegu) Ja Hyeong Kim (Ulsan University) Hyung Young Kim (Pusan National University) Jin A Jung (Dong-A University) Hyang Ok Woo (Gyeongsang National University) Jeom-Kyu Lee (Korea Centers for Disease Control and Prevention) Woo-Sung Chang (Korea Centers for Disease Control and Prevention) Nam Hee Do (Korea Institute of Child Care and Education) Hyejoo Cho (Korea Institute of Child Care and Education) Soo-JongHong (University of Ulsan)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.12 No.1
발행연도
2020.1
수록면
72 - 85 (14page)

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Purpose: Data are lacking on the association between the allergic rhinitis (AR) phenotype and sensitization to specific allergens or bronchial hyperresponsiveness (BHR) in children. We here investigated risk factors and comorbidities, including sensitization to specific allergens and BHR, for the AR phenotype by AR and its Impact on Asthma (ARIA) classification in a general population-based birth cohort study. Methods: We enrolled 606 children aged 7 years from the Panel Study of Korean Children. The AR phenotype was assigned in accordance with the ARIA classification in children. Skin prick tests and Provocholine provocation test were performed. Risk factors and comorbidities for AR phenotypes were then analyzed.Results: The prevalence of mild and moderate to severe AR in our study cohort was 37.2% and 8.8%, respectively. Recent use of analgesics or antipyretics and current cat ownership were associated with the risk of mild persistent AR. Sensitizations to Dermatophagoides Pteronyssinus (Der p), Japanese hop and cat were associated with moderate to severe persistent AR. Children with moderate to severe AR had a higher risk of current asthma and BHR compared to mild AR cases (adjusted odds ratio [aOR], 5.26; 95% confidence interval [CI], 1.77–15.62). Moderate to severe AR with allergic sensitization was associated with the highest risk of BHR (aOR, 11.77; 95% CI, 3.40–40.74). Conclusions: Moderate to severe-persistent AR is more closely related to respiratory comorbidities and sensitizations than mild AR. Stratifying the AR phenotype by ARIA classification may assist in disease management.
#Allergic rhinitis #classification #risk factor #child #phenotype

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참고문헌 (36)

참고문헌 신청
Bousquet J / 2008 / Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) / Allergy 63(Suppl 86):8~160 google schola Bousquet J / 2010 / Development and implementation of guidelines in allergic rhinitis – an ARIA-GA2LEN paper / Allergy 65:1212~1221 google schola Bousquet J / 2012 / Practical guide to skin prick tests in allergy to aeroallergens / Allergy 67:18~24 google schola Brożek JL / 2017 / Allergic Rhinitis and its Impact on Asthma(ARIA)guidelines-2016 revision / J Allergy Clin Immunol 140:950~958 google schola Katelaris CH / 2012 / Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America / Clin Exp Allergy 42:186~207 google schola

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