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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 12 (12page)
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Background: The mortality risk of coronavirus disease 2019 (COVID-19) is higher in patients with older age, and many elderly patients are reported to require advanced respiratory support. Methods: We reviewed medical records of 98 patients aged ≥ 65 years who were hospitalized with COVID-19 during a regional outbreak in Daegu/Gyeongsangbuk-do province of Korea. The outcome measures were in-hospital mortality and the treatment with mechanical ventilation (MV) or high-flow nasal cannula (HFNC). Results: The median age of the patients was 72 years; 55.1% were female. Most (74.5%) had at least one underlying condition. Overall case fatality rate (CFR) was 20.4%, and median time to death after admission was 8 days. The CFR was 6.1% among patients aged 65–69 years, 22.7% among those aged 70–79 years, and 38.1% among those aged ≥ 80 years. The CFR among patients who required MV was 43.8%, and the proportion of patients received MV/HFNC was 28.6%. Nosocomial acquisition, diabetes, chronic lung diseases, and chronic neurologic diseases were significant risk factors for both death and MV/HFNC. Hypotension, hypoxia, and altered mental status on admission were also associated with poor outcome. CRP > 8.0 mg/dL was strongly associated with MV/HFNC (odds ratio, 26.31; 95% confidence interval, 7.78–88.92; P < 0.001), and showed better diagnostic characteristics compared to commonly used clinical scores. Conclusion: Patients aged ≥ 80 years had a high risk of requiring MV/HFNC, and mortality among those severe patients was very high. Severe initial presentation and laboratory abnormalities, especially high CRP, were identified as risk factors for mortality and severe hospital course.
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참고문헌 (19)
참고문헌 신청
World Health Organization / 2020 / Coronavirus Disease 2019 (COVID-19) Situation Report - 65
Jin Yong Kim / 2020 / Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea / Journal of Korean Medical Science 35(7):1~7
Zou L / 2020 / SARS-CoV-2 viral load in upper respiratory specimens of infected patients / N Engl J Med 382(12):1177~1179
Tian S / 2020 / Characteristics of COVID-19 infection in Beijing / J Infect 80(4):401~406
Wu C / 2020 / Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China / JAMA Intern Med
Jin Yong Kim / 2020 / Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea / Journal of Korean Medical Science 35(7):1~7
Zou L / 2020 / SARS-CoV-2 viral load in upper respiratory specimens of infected patients / N Engl J Med 382(12):1177~1179
Tian S / 2020 / Characteristics of COVID-19 infection in Beijing / J Infect 80(4):401~406
Wu C / 2020 / Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China / JAMA Intern Med
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