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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 12 - 21 (10page)
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초록· 키워드
오류제보하기
Primary aldosteronism (PA) is the most common cause of secondary hypertension, and is associated with an increased incidence of cardiovascular events. PA itself is clinically classified into the following two types: unilateral PA, mostly composed of aldosteroneproducing adenoma (APA); and bilateral hyperaldosteronism, consisting of multiple aldosterone-producing micronodules (APMs) and aldosterone-producing diffuse hyperplasia. Histopathologically, those disorders above are all composed of compact and clear cells. The cellular morphology in the above-mentioned aldosterone-producing disorders has been recently reported to be closely correlated with patterns of somatic mutations of ion channels including KCNJ5, CACNA1D, ATP1A1, ATP2B3, and others. In addition,in non-pathological adrenal glands, APMs are frequently detected regardless of the status of the renin-angiotensin-aldosterone system (RAAS). Aldosterone-producing nodules have been also proposed as non-neoplastic nodules that can be identified by hematoxylin and eosin staining. These non-neoplastic CYP11B2-positive nodules could represent possible precursors of APAs possibly due to the presence of somatic mutations. On the other hand, aging itself also plays a pivotal role in the development of aldosterone-producing lesions. For instance, the number of APMs was also reported to increase with aging. Therefore, recent studies indicated the novel classification of PA into normotensive PA (RAAS-independent APM) and clinically overt PA.
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참고문헌 (58)
참고문헌 신청
Funder JW / 2011 / Medicine : the genetics of primary aldosteronism / Science 331:685~686
Rossi GP / 2006 / A prospective study of the prevalence of primary aldosteronism in 1, 125 hypertensive patients / J Am Coll Cardiol 48:2293~2300
Williams JS / 2006 / Prevalence of primary hyperaldosteronism in mild to moderate hypertension without hypokalaemia / J Hum Hypertens 20:129~136
Byrd JB / 2018 / Primary aldosteronism : practical approach to diagnosis and management / Circulation 138:823~835
Nishimoto K / 2010 / Adrenocortical zonation in humans under normal and pathological conditions / J Clin Endocrinol Metab 95:2296~2305
Rossi GP / 2006 / A prospective study of the prevalence of primary aldosteronism in 1, 125 hypertensive patients / J Am Coll Cardiol 48:2293~2300
Williams JS / 2006 / Prevalence of primary hyperaldosteronism in mild to moderate hypertension without hypokalaemia / J Hum Hypertens 20:129~136
Byrd JB / 2018 / Primary aldosteronism : practical approach to diagnosis and management / Circulation 138:823~835
Nishimoto K / 2010 / Adrenocortical zonation in humans under normal and pathological conditions / J Clin Endocrinol Metab 95:2296~2305
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