Aging increases oxidative stress in semen

Mitsuru Nago; Akane Arichi; Naoki Omura; Yuka Iwashita; Toshihiro Kawamura; Yasushi Yumura

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자료유형: 학술저널

저자정보: Mitsuru Nago (Denentoshi Ladies Clinic) Akane Arichi (Denentoshi Ladies Clinic) Naoki Omura (Denentoshi Ladies Clinic) Yuka Iwashita (Denentoshi Ladies Clinic) Toshihiro Kawamura (Denentoshi Ladies Clinic) Yasushi Yumura (Yokohama City University Medical Center Yokohama Japan)

저널정보: 대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.62 No.2

발행연도: 2021.1

수록면: 233 - 238 (6page)

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Purpose: As age increases, oxidative stress increases, sperm motility decreases, and DNA fragmentation increases. To date, reports of age-related effects on semen have focused on reactive oxygen species (ROS) or total antioxidant capacity (TAC) as indicators of oxidative stress. However, assessments of ROS and TAC must be considered within a more comprehensive context in order to correctly evaluate oxidative stress and interpret findings. In this regard, the purpose of this study was to investigate the relationship between the static oxidation reduction potential (sORP) and paternal age with the goal of using the sORP as an indicator of semen oxidative stress. Materials and Methods: Semen samples from 173 men were analyzed for the following parameters: volume, motility, and beat cross frequency (BCF). The sORP was measured by using the MiOXSYS™ system. The correlation between semen parameters and the sORP level was analyzed as a function of age. The rate of sORP positivity was compared between men <34 and ≥34 years of age, with a positive sORP defined as a level ≥1.38. Results: Volume, motility, and BCF were negatively correlated with age (p<0.001). The semen sORP level was positively correlated with age (p<0.05). The rate of sORP positivity was significantly increased in men ≥34 years of age compared with that in men <34 years of age (33% compared with 12%, respectively; p<0.01). Conclusions: The sORP may play a role in age-related decreases in semen parameters (volume, motility, and BCF). The rate of sORP positivity increased significantly after 34 years of age.

#Aging #Oxidation reduction #Oxidative stress #Semen #Sperm

참고문헌 (29)

참고문헌 신청

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