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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한비만학회 Journal of Obesity & Metabolic Syndrome Journal of Obesity & Metabolic Syndrome Vol.29 No.3
- 발행연도
- 2020.1
- 수록면
- 215 - 221 (7page)
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초록· 키워드
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Background: Sodium-glucose cotransporter 2 inhibitors reduce the risk of cardiovascular death in individuals with type 2 diabetes mellitus (T2DM) and cardiovascular disease, but the effect of these inhibitors on early cardiovascular disease remains unknown. This study evaluated the effect of dapagliflozin on the metabolic profiles and endothelial cell function in obese patients with T2DM without established cardiovascular disease. Methods: We enrolled 140 patients with a mean age, weight, and body mass index (BMI) of 47 years, 83 kg, and 30.3 kg/m2, respectively. Dapagliflozin (10 mg daily for 6 months) was administered to obese patients with T2DM without established cardiovascular disease. Participants’ weight, BMI, body fat mass (BFM), muscle mass, glycosylated hemoglobin (HbA1c), lipid profile, waist to hip ratio (WHR), and pulse wave velocity (PWV) were measured at baseline and after 6 months. Results: Participants experienced statistically significant reductions in their HbA1c, fasting plasma glucose, low-density lipoprotein cholesterol, total cholesterol, body weight, BMI, WHR, BFM, and aortic PWV, without a significant change in their muscle mass, extracellular fluid, or intracellular volume. Statistically significant reductions in aortic PWV were associated with a decrease in BFM, visceral fat, WHR, and homeostatic model assessment of insulin resistance. Conclusion: Dapagliflozin may be beneficial in preventing early cardiovascular disease in obese patients with T2DM without established cardiovascular disease.
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참고문헌 (27)
참고문헌 신청
American Diabetes Association / 2018 / Cardiovascular disease and risk management: Standards of Medical Care in Diabetes—2018 / Diabetes Care :S86~S104
American Diabetes Association / 2019 / Cardiovascular disease and risk management: Standards of Medical Care in Diabetes—2019 / Diabetes Care 42:S103~S123
Bhaskaran K / 2018 / Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3.6 million adults in the UK / Lancet Diabetes Endocrinol 6:944~953
American Diabetes Association / 2019 / Obesity management for the treatment of type 2 diabetes : Standards of Medical Care in Diabetes 2019 / Diabetes Care 42:S81~S89
Look AHEAD Research Group / 2013 / Cardiovascular effects of in-tensive lifestyle intervention in type 2 diabetes / N Engl J Med 369:145~154
American Diabetes Association / 2019 / Cardiovascular disease and risk management: Standards of Medical Care in Diabetes—2019 / Diabetes Care 42:S103~S123
Bhaskaran K / 2018 / Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3.6 million adults in the UK / Lancet Diabetes Endocrinol 6:944~953
American Diabetes Association / 2019 / Obesity management for the treatment of type 2 diabetes : Standards of Medical Care in Diabetes 2019 / Diabetes Care 42:S81~S89
Look AHEAD Research Group / 2013 / Cardiovascular effects of in-tensive lifestyle intervention in type 2 diabetes / N Engl J Med 369:145~154
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Efficacy of Body Weight Reduction on the SGLT2 Inhibitor in People with Type 2 Diabetes Mellitus
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제2형 당뇨병 환자에서 Dapagliflozin이 혈당과 심혈관계질환 위험인자에 미치는 영향 및 안전성
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비알콜성 지방간을 가진 제2형 당뇨병 환자에서 지방간 개선에 대한 Dapagliflozin의 효과
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Off-target Effects of Sodium-glucose Cotransporter 2 (SGLT-2) Inhibitor in Cardiovascular Disease
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Benefit and Safety of Sodium-Glucose Co-Transporter 2 Inhibitors in Older Patients with Type 2 Diabetes Mellitus
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Cardiovascular Outcome Trials of Sodium Glucose Cotransporter 2 Inhibitor and Its Possible Cardioprotective Mechanism
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Sodium-glucose Co-transporter 2 Inhibitors: a New Path for Heart Failure Treatment
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제2형 당뇨병 환자에서 장기간의 Sodium-glucose Cotransporter 2 억제제 치료가 신장기능에 미치는 효과
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Socioeconomic Disparities in Cardiovascular Diseases in South Korea
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Effect of Dapagliflozin as an Add-on Therapy to Insulin on the Glycemic Variability in Subjects with Type 2 Diabetes Mellitus (DIVE): A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study
Diabetes and Metabolism Journal
2021 .01
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당뇨병 치료약제와 심혈관 질환
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Effect of Sodium-Glucose Cotransporter 2 Inhibitors on Weight Reduction in Overweight and Obese Populations without Diabetes: A Systematic Review and a Meta-Analysis
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Resistance Exercise and Cardiovascular Disease in Diabetes Mellitus
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