지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.9 No.6
- 발행연도
- 2017.1
- 수록면
- 509 - 516 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma. In this study, we investigated the relationships between sensitization to mold and lung function parameters in children with asthma. Methods: We retrospectively reviewed clinical data from 551 asthmatic subjects. We selected subjects who met clinical diagnostic criteria of asthma. Their spirometry, methacholine challenge tests, and measurements of blood eosinophils, serum IgE, eosinophil cationic protein (ECP) and fractional exhaled nitric oxide (FeNO) results were included. Skin prick testing (SPT) results with 13 common aeroallergens in Korea including house dust mites, animal dander, pollen, cockroach and mold were reviewed. Subjects were divided into 3 groups according to their SPT results. Subjects who showed no positive result to any aeroallergen were designated as group 1 (non-sensitized). Group 2 represented subjects who were sensitized to aeroallergens other than mold (other allergen-sensitized) and group 3 included subjects who were sensitized to mold allergens (mold-sensitized). Results: Among the 551 asthmatic subjects, 67 (12.2%) were sensitized to mold and 366 (66.4%) were sensitized to other aeroallergens. The log mean IgE levels were higher in groups 2 (5.96±1.14 IU/mL) and 3 (5.81±0.97 IU/mL) compared to group 1 (3.88±1.68 IU/mL). Blood eosinophils, ECP and FeNO concentrations were significantly higher in groups 2 and 3, but no significant difference was found between the 2 groups. The mean FEV1 value was significantly lower in group 3 (86.9±12.1%pred) than in groups 2 (92.0±14.8%pred) and 1 (93.4±15.4%pred). The log mean methacholine PC20 was significantly lower in group 3 (0.08±1.91 mg/mL) than in groups 2 (1.31±1.69 mg/mL) and 1 (2.29±1.66 mg/mL). Conclusions: We observed a differential association between mold and other aeroallergen sensitization, and severity of asthma. Sensitization to mold is associated with lower lung function and increased airway hyper-responsiveness in children with asthma. Mold sensitization could be an important factor determining asthma severity particularly airflow limitation in children.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Gent JF / 2012 / Household mold and dust allergens: exposure, sensitization and childhood asthma morbidity / Environ Res 118:86~93
Ezeamuzie CI / 2000 / IgE-mediated sensitization to mould allergens among patients with allergic respiratory diseases in a desert environment / Int Arch Allergy Immunol 121:300~307
Antonio Moreno / 2016 / Orthologous Allergens and Diagnostic Utility of Major Allergen Alt a 1 / Allergy, Asthma & Immunology Research 8(5):428~437
Menzies D / 2011 / Aspergillus sensitization is associated with airflow limitation and bronchiectasis in severe asthma / Allergy 66:679~685
Vicencio AG / 2014 / Fungal sensitization in childhood persistent asthma is associated with disease severity / Pediatr Pulmonol 49:8~14
Ezeamuzie CI / 2000 / IgE-mediated sensitization to mould allergens among patients with allergic respiratory diseases in a desert environment / Int Arch Allergy Immunol 121:300~307
Antonio Moreno / 2016 / Orthologous Allergens and Diagnostic Utility of Major Allergen Alt a 1 / Allergy, Asthma & Immunology Research 8(5):428~437
Menzies D / 2011 / Aspergillus sensitization is associated with airflow limitation and bronchiectasis in severe asthma / Allergy 66:679~685
Vicencio AG / 2014 / Fungal sensitization in childhood persistent asthma is associated with disease severity / Pediatr Pulmonol 49:8~14
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
곰팡이에 감작된 소아 천식 환자 가정내 환경유해물질 농도와 폐기능의 상관관계
한국환경보건학회지
2020 .12
-
Trends of Sensitization to Inhalant Allergens in Korean Children Over the Last 10 Years
Yonsei Medical Journal
2020 .01
-
영아 아토피피부염에서 알레르기 감작과 IgE 매개 여부에따른 임상 양상
Allergy Asthma & Respiratory Diseases
2017 .01
-
학령전기 만성 기침 환아에서 알레르기 감작의 위험 요인
Allergy Asthma & Respiratory Diseases
2015 .01
-
Allergic Sensitization Driving Immune Phenotyping and Disease Severity in a Mouse Model of Asthma
Allergy, Asthma & Immunology Research
2023 .03
-
Current Asthma Prevalence Using Methacholine Challenge Test in Korean Children from 2010 to 2014
Journal of Korean Medical Science
2021 .01
-
영아기에 실내 반려동물의 노출이 소아의 동물 항원 감작과 천식에 미치는 영향
Allergy Asthma & Respiratory Diseases
2019 .01
-
Impacts of Asthma in Patients With Bronchiectasis: Findings From the KMBARC Registry
Allergy, Asthma & Immunology Research
2023 .01
-
중증천식의 치료
대한내과학회지
2018 .01
-
소아천식에서 천식 조절 상태 평가 도구의 유용성
Allergy Asthma & Respiratory Diseases
2015 .01
-
Associated Factors for Asthma Severity in Korean Children: A Korean Childhood Asthma Study
Allergy, Asthma & Immunology Research
2020 .01
-
소아에서 비타민 D와 천식의 연관성
Allergy Asthma & Respiratory Diseases
2016 .01
-
교육대학교 학생의 천식에 대한 지식, 공감 및 천식아동에 대한 태도
Child Health Nursing Research
2016 .01
-
소아청소년 알레르기비염과 비알레르기비염 환자의 임상적 특징
Allergy Asthma & Respiratory Diseases
2020 .01
-
Risk, Mechanisms and Implications of Asthma-Associated Infectious and Inflammatory Multimorbidities (AIMs) among Individuals With Asthma: a Systematic Review and a Case Study
Allergy, Asthma & Immunology Research
2021 .09
-
Association of Specific Immunoglobulin E to Staphylococcal Enterotoxin with Airway Hyperresponsiveness in Asthma Patients
Tuberculosis and Respiratory Diseases
2016 .01
-
대기 미세먼지가 천식 발생과 조절에 미치는 영향
Allergy Asthma & Respiratory Diseases
2015 .01
-
한국의 소아 천식의 연구 현황과 과제
Allergy Asthma & Respiratory Diseases
2018 .09
-
단일기관 소아 알레르기질환 환자에서 최근 흡입항원 감작 패턴의 변화: 단일기관 연구
Allergy Asthma & Respiratory Diseases
2019 .01
-
Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma
Tuberculosis and Respiratory Diseases
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0