지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.9 No.6
- 발행연도
- 2017.1
- 수록면
- 540 - 549 (10page)
이용수
초록· 키워드
오류제보하기
Interleukin (IL)-17 plays an important role in rhinitis and the level thereof correlates with the severity of disease. However, no mouse model for IL-17-dominant rhinitis has yet been developed. Our objective was to establish a mouse model of IL-17-dominant rhinitis via intranasal application of polyinosinic-polycytidylic acid (abbreviated as Poly(I:C)). Mice were divided into 6 groups (n=8 for each group); 1) 1 negative control group, 2) 1 positive control group (OVA/alum model), 3) 2 Poly(I:C) groups (10 or 100 μg), and 4) 2 OVA/Poly(I:C) groups (10 or 100 μg). The positive control group was treated with the conventional OVA/alum protocol. In the Poly(I:C) and OVA/Poly(I:C) groups, phosphate-buffered saline or an OVA solution plus Poly(I:C) were administered. The OVA/Poly(I:C) groups exhibited significantly greater neutrophil infiltration and increased IL-17/interferon γ expression compared with the other groups. However, the levels of total immunoglobulin E (IgE), OVA-specific IgE, eosinophil infiltration, IL-4, IL-5, IL-6, and IL-10 were significantly lower in the OVA/Poly(I:C) groups than in mice subjected to conventional Th2-dominant OVA/alum treatment (the positive control group). IL-17 and neutrophil measurement, chemokine (C-X-C motif) ligand 1 immunohistochemistry, and confocal microscopy revealed increased numbers of IL-17-secreting cells in the nasal mucosa of the OVA/Poly(I:C) groups, which included natural killer cells, CD4 T cells, and neutrophils. In conclusion, we developed a mouse model of IL-17-dominant rhinitis using OVA together with Poly(I:C). This model will be useful in research on neutrophil- or IL-17-dominant rhinitis.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Weaver CT / 2013 / The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin / Annu Rev Pathol 8:477~512
Ciprandi G / 2009 / Serum interleukin-17 levels are related to clinical severity in allergic rhinitis / Allergy 64:1375~1378
Quan SH / 2012 / Contribution of interleukin 17A to the development and regulation of allergic inflammation in a murine allergic rhinitis model / Ann Allergy Asthma Immunol 108:342~350
Halwani R / 2013 / T helper 17 cells in airway diseases: from laboratory bench to bedside / Chest 143:494~501
Vultaggio A / 2012 / Poly(I:C) promotes the production of IL-17A by murine CD1d-driven invariant NKT cells in airway inflammation / Allergy 67:1223~1232
Ciprandi G / 2009 / Serum interleukin-17 levels are related to clinical severity in allergic rhinitis / Allergy 64:1375~1378
Quan SH / 2012 / Contribution of interleukin 17A to the development and regulation of allergic inflammation in a murine allergic rhinitis model / Ann Allergy Asthma Immunol 108:342~350
Halwani R / 2013 / T helper 17 cells in airway diseases: from laboratory bench to bedside / Chest 143:494~501
Vultaggio A / 2012 / Poly(I:C) promotes the production of IL-17A by murine CD1d-driven invariant NKT cells in airway inflammation / Allergy 67:1223~1232
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
柴胡가 OVA로 유발된 BALB/c mice의 알레르기성 비염 모델에 미치는 영향
동의생리병리학회지
2015 .12
-
柴胡가 OVA로 유발된 BALB/c mice의 알레르기성 비염 모델에 미치는 영향
동의생리병리학회지
2015 .01
-
The Role of IL-17 in a Lipopolysaccharide-Induced Rhinitis Model
Allergy, Asthma & Immunology Research
2017 .01
-
The role of IL-17A in particulate matter-exacerbated inflammatory response of allergic asthma mice
한국실험동물학회 학술발표대회 논문집
2021 .07
-
쥐 비만세포 (RBL-2H3)와 OVA/alum 감작 마우스에서 치자 추출물의 알레르기 염증 억제 효과
대한한방소아과학회지
2018 .01
-
세신 전탕액 경구투여가 천식 억제 및 면역조절에 미치는 영향
대한침구의학회지
2016 .01
-
Effect of Proparacaine in a Mouse Model of Allergic Rhinitis
Clinical and Experimental Otorhinolaryngology
2017 .01
-
Intranasal Treatment With 1, 25-Dihydroxyvitamin D3 Alleviates Allergic Rhinitis Symptoms in a Mouse Model
Allergy, Asthma & Immunology Research
2019 .01
-
난알부민으로 알레르기 비염이 유발된 마우스에서 형개의 개선효과
대한본초학회지(본초분과학회지)
2015 .01
-
Antiallergic Effect of Hizikia fusiformis in an Ovalbumin-Induced Allergic Rhinitis Mouse Model
Clinical and Experimental Otorhinolaryngology
2019 .01
-
Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy
Allergy, Asthma & Immunology Research
2022 .07
-
Antiallergic Function of KR62980, a Peroxisome Proliferator- Activated Receptor-γ Agonist, in a Mouse Allergic Rhinitis Model
Allergy, Asthma & Immunology Research
2015 .01
-
Anti-interleukin-33 Reduces Ovalbumin-Induced Nephrotoxicity and Expression of Kidney Injury Molecule-1
International Neurourology Journal
2016 .01
-
결명자 추출물의 난알부민 감작으로 천식이 유발된 마우스에서의 개선 효과
대한본초학회지(본초분과학회지)
2015 .01
-
Anti-inflammatory effect of Allium hookeri in the OVA-induced allergic rhinitis mouse model
대한체질인류학회 학술대회 연제 초록
2019 .05
-
Gallic Acid alleviates inflammation in an OVA-induced allergic rhinitis mouse model by regulating of Th1/Th2/Th17 cytokines production
대한체질인류학회 학술대회 연제 초록
2018 .05
-
Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB pathway
해부·생물인류학
2023 .09
-
Anti-Interleukin-9 Antibody Increases the Effect of Allergen-Specific Immunotherapy in Murine Allergic Rhinitis
Allergy, Asthma & Immunology Research
2017 .01
-
An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response
Allergy, Asthma & Immunology Research
2020 .01
-
Anti-allergic rhinitis activity of Euonymus alatus by inhibiting NF-kB signaling and enhancing Th1/Th2 balance
대한체질인류학회 학술대회 연제 초록
2021 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0