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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 819 - 824 (6page)
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초록· 키워드
오류제보하기
Korea has been divided into South Korea and North Korea for over 70 years. DNA profiles of the North Korean population have never been reported in the Y-chromosome STR Haplotype Reference Database (YHRD; https ://yhrd.org). To investigate genetic features of Y-chromosome STR haplotypes of the North Korean population for the first time. Genomic DNA was isolated from 838 cigarette butts assumed to have been smoked by North Korean men and amplified with PowerPlex Y23 (PPY23) kit. Statistical parameters were calculated using Nei’s formula and analysis of molecular variance (AMOVA). Multidimensional scaling (MDS) plot was constructed by the AMOVA tool and neighbor-joining (NJ) tree was constructed by MEGA 6.06. A total of 121 haplotypes were analyzed for PPY23 loci from a sample population. Haplotype diversity and discrimination capacity were 0.9992 and 0.9837, respectively. Genetic diversities ranged from 0.2981 to 0.9716. For the 16 Y-filer loci and eight minimal loci, respectively 90.9 and 82.6% of the matched haplotypes were estimated to belong to haplogroup O, representing the Southeast and East Asian type. The MDS plot and NJ tree indicated that the samples are most closely related to South Korean. In addition, p-value in the pairwise comparison to the South Korean was slightly above statistical significance (p = 0.0534). The Y-STR haplotypes of the samples were unique and highly genetically polymorphic. Despite the separation between North and South Korea for 70 years, they can still be considered a single genetic population, based on Y-STR haplotypes.
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참고문헌 (17)
참고문헌 신청
Bhoopat T / 2003 / Identification of DYS385 allele variants by using shorter amplicons and Northern Thai haplotype data / J Forensic Sci 48:1108~1112
Butler JM / 2003 / Recent developments in Y-short tandem repeat and Y-single nucleotide polymorphism analysis / Forensic Sci Rev 15(2):91~111
Hammer MF / 2006 / Dual origins of the Japanese: common ground for hunter-gatherer and farmer Y chromosomes / J Hum Genet 51(1):47~58
Jin HJ / 2003 / Y-chromosomal DNA haplogroups and their implications for the dual origins of the Koreans / Hum Genet 114:27~35
Jin HJ / 2009 / The peopling of Korea revealed by analyses of mitochondrial DNA and Y-chromosomal markers / PLoS One 4(1):e4210
Butler JM / 2003 / Recent developments in Y-short tandem repeat and Y-single nucleotide polymorphism analysis / Forensic Sci Rev 15(2):91~111
Hammer MF / 2006 / Dual origins of the Japanese: common ground for hunter-gatherer and farmer Y chromosomes / J Hum Genet 51(1):47~58
Jin HJ / 2003 / Y-chromosomal DNA haplogroups and their implications for the dual origins of the Koreans / Hum Genet 114:27~35
Jin HJ / 2009 / The peopling of Korea revealed by analyses of mitochondrial DNA and Y-chromosomal markers / PLoS One 4(1):e4210
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