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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 36 - 41 (6page)
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Purpose: A laparoscopic colectomy in colorectal-cancer patients is usually associated with a high risk of postoperative nausea and vomiting (PONV). The purpose of this study is to evaluate the efficacy of injection of long-acting 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist for the reduction of PONV in patients with colorectal cancer. Methods: A total of 48 patients scheduled to undergo a laparoscopic colectomy for colorectal cancer were randomized in a double-blinded fashion. Patients were randomly allocated to 1 of 2 groups and assigned to receive either 0.3 mg of ramosetron intravenously (group A, n = 25) or 2 mL of normal saline (placebo) (group B, n = 22) immediately after the operation. The incidence of PONV, the nausea severity scale score, the visual analogue scale (VAS) score for pain, the total amount of patient-controlled analgesia used, the recovery of bowel function, and morbidities were assessed at 1 hour and at 24, 48, and 72 hours after surgery. Results: The baseline and the operative characteristics were similar between the groups (P > 0.05). The number of cases without PONV (complete response) was higher for group A (ramosetron) than group B (normal saline): 24 hours after surgery, 92.0% (23 of 25) for group A versus 54.5% (12 of 22) for group B; 48 hours after surgery, 92% (23 of 25) for group A versus 81.8% (18 of 22) for group B (both P < 0.05). No serious adverse events occurred. Conclusion: Postoperative ramosetron injection is effective for the prevention of PONV after a laparoscopic colectomy in colorectal-cancer patients.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Apfel CC / 2004 / A factorial trial of six interventions for the prevention of postoperative nausea and vomiting / N Engl J Med 350:2441~2451
Tramer MR / 2004 / Strategies for postoperative nausea and vomiting / Best Pract Res Clin Anaesthesiol 18:693~701
Cohen MM / 1994 / The postoperative interview: assessing risk factors for nausea and vomiting / Anesth Analg 78:7~16
Gan TJ / 1996 / Double-blind, randomized comparison of ondansetron and intraoperative propofol to prevent postoperative nausea and vomiting / Anesthesiology 85:1036~1042
Zmora O / 2009 / Laparoscopic colectomy is associated with decreased postoperative gastrointestinal dysfunction / Surg Endosc 23:87~89
Tramer MR / 2004 / Strategies for postoperative nausea and vomiting / Best Pract Res Clin Anaesthesiol 18:693~701
Cohen MM / 1994 / The postoperative interview: assessing risk factors for nausea and vomiting / Anesth Analg 78:7~16
Gan TJ / 1996 / Double-blind, randomized comparison of ondansetron and intraoperative propofol to prevent postoperative nausea and vomiting / Anesthesiology 85:1036~1042
Zmora O / 2009 / Laparoscopic colectomy is associated with decreased postoperative gastrointestinal dysfunction / Surg Endosc 23:87~89
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