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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 88 - 93 (6page)
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Purpose: Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed to evaluate the association between c-Met and lymphangiogenic factors and to elucidate the prognostic significance of c-Met in patients with CRC. Methods: A total of 379 tissue samples were obtained from surgically resected specimens from patients with CRC at Soonchunhyang University Cheonan Hospital between January 2002 and December 2010. The expressions of c-Met, vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, and podoplanin were examined using immunohistochemistry. The expression of c-Met and clinical factors were analyzed. Results: Of the 379 tissues, 301 (79.4%) had c-Met expression. High expression of c-Met in tumor cells was significantly associated with high expression of VEGF-C (P < 0.001) and VEGFR-3 (P = 0.001). However, no statistically significant association with podoplanin (P = 0.587) or VEGF-D (P = 0.096) was found. Of the 103 evaluable patients, expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = 0.020), positive lymph node status (P = 0.038), and high expression of VEGF-C (P = 0.020). However, no statistically significant association with podoplanin (P = 0.518), VEGFR-3 (P = 0.085), VEGF-D (P = 0.203), or overall survival (P = 0.360) was found. Conclusion: Our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic markers, but c-Met expression in patients with CRC is not a prognostic indicator for overall survival.
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참고문헌 (19)
참고문헌 신청
Siegel R / 2012 / Cancer statistics, 2012 / CA Cancer J Clin 62:10~29
Vather R / 2009 / Lymph node evaluation and long-term survival in Stage II and Stage III colon cancer: a national study / Ann Surg Oncol 16:585~593
Sundlisaeter E / 2007 / Lymphangiogenesis in colorectal cancer--prognostic and therapeutic aspects / Int J Cancer 121:1401~1409
Zwaans BM / 2007 / Potential therapeutic strategies for lymphatic metastasis / Microvasc Res 74:145~158
Jussila L / 2002 / Vascular growth factors and lymphangiogenesis / Physiol Rev 82:673~700
Vather R / 2009 / Lymph node evaluation and long-term survival in Stage II and Stage III colon cancer: a national study / Ann Surg Oncol 16:585~593
Sundlisaeter E / 2007 / Lymphangiogenesis in colorectal cancer--prognostic and therapeutic aspects / Int J Cancer 121:1401~1409
Zwaans BM / 2007 / Potential therapeutic strategies for lymphatic metastasis / Microvasc Res 74:145~158
Jussila L / 2002 / Vascular growth factors and lymphangiogenesis / Physiol Rev 82:673~700
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