지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한미용성형외과학회 Archives of Aesthetic Plastic Surgery Archives of Aesthetic Plastic Surgery Vol.22 No.3
- 발행연도
- 2016.1
- 수록면
- 129 - 134 (6page)
이용수
초록· 키워드
오류제보하기
Background The purpose of this study was to examine the effects of a single administration of vascular endothelial growth factor (VEGF) in promoting the angiogenesis and thereby reducing the formation of capsular contracture. Methods We treated 24 female Sprague-Dawley rats with (1) 5 mM Tris Buffer and 150 mM NaCl 0.1 cc, (2) VEGF 15 μg/0.1 cc, (3) VEGF 150 μg/0.1 cc during placement of the implant, or (4) VEGF 150 μg/0.1 cc and VEGF 300 μg/0.2 cc. We histopathologically measured the thickness of the capsule and the number of blood vessels. Results All experimental groups had a significant difference in the thickness of the capsule compared to the control group (P<0.001). There was no significant difference between experimental group 2 and experimental group 3. The number of blood vessels formed around the capsule was significantly greater in all the experimental groups compared with the control group (P<0.05). There was no significant difference between the experimental groups. There was a significant negative correlation between the thickness of the capsule and the number of blood vessels (Spearman’s correlation coefficient, 0.2732; P<0.0001). Conclusions A single administration of VEGF reduced formation of the capsule and increased the vascularity around the implant, supporting the hypothesis that prevention of tissue ischemia can be a treatment strategy for capsular contracture.
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참고문헌 (24)
참고문헌 신청
Tamboto H / 2010 / Subclinical (biofilm) infection causes capsular contracture in a porcine model following augmentation mammaplasty / Plast Reconstr Surg 126:835~842
Marques M / 2010 / Long-term follow-up of breast capsule contracture rates in cosmetic and reconstructive cases / Plast Reconstr Surg 126:769~778
Barnsley GP / 2006 / Textured surface breast implants in the prevention of capsular contracture among breast augmentation patients: a meta-analysis of randomized controlled trials / Plast Reconstr Surg 117:2182~2190
Collis N / 2000 / Ten-year review of a prospective randomized controlled trial of textured versus smooth subglandular silicone gel breast implants / Plast Reconstr Surg 106:786~791
Handel N / 2006 / A long-term study of outcomes, complications, and patient satisfaction with breast implants / Plast Reconstr Surg 117:757~767
Marques M / 2010 / Long-term follow-up of breast capsule contracture rates in cosmetic and reconstructive cases / Plast Reconstr Surg 126:769~778
Barnsley GP / 2006 / Textured surface breast implants in the prevention of capsular contracture among breast augmentation patients: a meta-analysis of randomized controlled trials / Plast Reconstr Surg 117:2182~2190
Collis N / 2000 / Ten-year review of a prospective randomized controlled trial of textured versus smooth subglandular silicone gel breast implants / Plast Reconstr Surg 106:786~791
Handel N / 2006 / A long-term study of outcomes, complications, and patient satisfaction with breast implants / Plast Reconstr Surg 117:757~767
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