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논문 기본 정보

자료유형
학술저널
저자정보
Abhilash Chandra (Department of Nephrology Dr. RMLIMS Lucknow UP India)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.35 No.3
발행연도
2016.1
수록면
165 - 168 (4page)

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Background: There is an increased prevalence of hypothyroidism in chronic kidney disease (CKD) patients as the glomerular filtration rate falls. However, there is a paucity of Indian data in this respect. Methods: A cross-sectional analysis was performed based on the database of the information system of a tertiary care hospital in northern India to retrieve results of nephrology CKD outpatients (> 18 years of age) from September 2013 to October 2015 to determine the prevalence of hypothyroidism in the nonedialysis-dependent CKD population. Overt hypothyroidism was defined by a thyroid-stimulating hormone (TSH) level > 5.5 mIU/L and free T4 level < 0.89 ng/dL with clinical symptoms. Subclinical hypothyroidism was defined by a TSH level > 5.5 mIU/L and a free T4 level 0.89 ng/dL. Results: Among 1,863 CKD patients, 358 patients underwent biochemical analysis for hypothyroidism. Among these, 143 had biochemical subclinical hypothyroidism and 59 had overt hypothyroidism. Patients in the overt hypothyroid group had significantly higher TSH levels and a lower free T4 level than those in the nonhypothyroid group. Patients with hypothyroidism (both clinical and subclinical) had significantly lower serum albumin and serum calcium levels than those in the nonhypothyroid group. Intact parathyroid hormone was also significantly higher in the hypothyroid groups. An increased prevalence of hypothyroidism was observed in patients with a reduction in the glomerular filtration rate. Conclusion: There is growing evidence of increased prevalence of hypothyroidism in dialysis-independent CKD patients. A number of findings such as lower serum albumin, serum calcium, and hemoglobin levels and higher intact parathyroid hormone levels are seen in this group. Specific treatment can help improve these. Hence, there is a need to formulate guidelines to screen this population for hypothyroidism

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참고문헌 (19)

참고문헌 신청
Chonchol M / 2008 / Prevalence of subclinical hypothyroidism in patients with chronic kidney disease / Clin J Am Soc Nephrol 3:1296~1300 google schola Lo JC / 2005 / Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease / Kidney Int 67:1047~1052 google schola Targher G / 2009 / Prevalence of thyroid autoimmunity and subclinical hypothyroidism in persons with chronic kidney disease not requiring chronic dialysis / Clin Chem Lab Med 47:1367~1371 google schola Surks MI / 2007 / Age-specific distribution of serum thyro-tropin and antithyroid antibodies in the US population : implica-tions for the prevalence of subclinical hypothyroidism / J Clin Endocrinol Metab 92:4575~4582 google schola Ramirez G / 1976 / Thyroid dysfunction in uremia : evidence for thyroid and hypophyseal abnormalities / Ann Intern Med 84:672~676 google schola

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