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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 292 - 297 (6page)
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초록· 키워드
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Sodium-glucose cotransporter-2 (SGLT2) inhibitors are effective for overweight diabetic patients through the induction of glucosuria. However, SGLT2 inhibitors are not recommended for patients with advanced chronic kidney disease (CKD) because they may aggravate renal function and thus become less effective in controlling blood glucose in this patient population. We suggest that adequate hydration would be helpful to prevent the side effects of SGLT2 inhibitors in diabetic patients with advanced CKD. In this study, we review five cases of SGLT2 inhibitor therapy, specifically with dapagliflozin, for the treatment of diabetes mellitus in patients with advanced CKD. The patients experienced dramatic weight reduction, improved glucose control, and further benefits without aggravation of renal function.
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등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Look AHEAD Research Group / 2014 / Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial / Lancet Diabetes Endocrinol 2:801~809
Friedman AN / 2013 / Short-term changes after a weight reduction intervention in advanced diabetic nephropathy / Clin J Am Soc Nephrol 8:1892~1898
Morales E / 2003 / Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies / Am J Kidney Dis 41:319~327
Komoroski B / 2009 / Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects / Clin Pharmacol Ther 85:520~526
Heerspink HJ / 2016 / Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications / Circulation 134:752~772
Friedman AN / 2013 / Short-term changes after a weight reduction intervention in advanced diabetic nephropathy / Clin J Am Soc Nephrol 8:1892~1898
Morales E / 2003 / Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies / Am J Kidney Dis 41:319~327
Komoroski B / 2009 / Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects / Clin Pharmacol Ther 85:520~526
Heerspink HJ / 2016 / Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications / Circulation 134:752~772
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