지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 193 - 199 (7page)
이용수
초록· 키워드
오류제보하기
Background: CD5-positive diffuse large B-cell lymphoma (CD5+ DLBCL) accounts for 5–10% of DLBCL cases and has poor patient outcomes. However, most studies on CD5+ DLBCL were performed in Japanese patients and only few data are available for Korean population. In this study, we investigated the clinical characteristics and prognostic im-pact of CD5 expression in Korean patients with bone marrow (BM) involvement of DLBCL. Methods: Patients who were initially diagnosed with BM involvement of de novo DLBCL from 2005 to 2013 were included. Clinicopathological features and outcomes of patients were com-pared between CD5+ and CD5 negative (CD5-) DLBCL. Results: Among a total of 57 patients, the number of patients with CD5+ and CD5- DLBCL were 13 and 44, respectively. Clinical and laboratory features of CD5+ DLBCL were not sig-nificantly different from those of CD5- DLBCL. The 3-year overall survival (OS) rates for CD5+ and CD5- DLBCL were 20.2% and 59.0%, respectively (P=0.031), and 3-year pro-gression-free survival (PFS) rates for CD5+ and CD5- DLBCL were 23.1% and 50.1%, re-spectively (P=0.055). Conclusion: CD5+ DLBCL with BM involvement showed an inferior survival tendency compared to CD5- DLBCL, and thorough evaluation of CD5 expression might be helpful to predict the prognosis of patients with DLBCL.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Swerdlow SH / 2008 / WHO classification of tumours of haematopoietic and lymphoid tissues / IARC Press
이현규 / 2013 / Clinical features and survival outcomes of patients with diffuse large B-cell lymphoma: analysis of web-based data from the Korean Lymphoma Working Party Registry / Blood Research 48(2):115~120
1993 / International Non-Hodgkin's Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin's lymphoma / N Engl J Med 329:987~994
Yamaguchi M / 1999 / De novo CD5-positive diffuse large B-cell lymphoma : clinical characteristics and therapeutic outcome / Br J Haematol 105:1133~1139
Yamaguchi M / 2002 / De novo CD5+ diffuse large B-cell lymphoma : a clinicopathologic study of 109 patients / Blood 99:815~821
이현규 / 2013 / Clinical features and survival outcomes of patients with diffuse large B-cell lymphoma: analysis of web-based data from the Korean Lymphoma Working Party Registry / Blood Research 48(2):115~120
1993 / International Non-Hodgkin's Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin's lymphoma / N Engl J Med 329:987~994
Yamaguchi M / 1999 / De novo CD5-positive diffuse large B-cell lymphoma : clinical characteristics and therapeutic outcome / Br J Haematol 105:1133~1139
Yamaguchi M / 2002 / De novo CD5+ diffuse large B-cell lymphoma : a clinicopathologic study of 109 patients / Blood 99:815~821
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Prognostic Implication of Semi-quantitative Immunohistochemical Assessment of CD20 Expression in Diffuse Large B-Cell Lymphoma
Journal of Pathology and Translational Medicine
2016 .01
-
Clinicopathologic implication of PD-L1 gene alteration in primary adrenal diffuse large B cell lymphoma
Journal of Pathology and Translational Medicine
2022 .01
-
Genomics of diffuse large B cell lymphoma
Blood Research
2021 .01
-
Genomics of diffuse large B cell lymphoma
Blood Research
2021 .04
-
Extrinsic Acquisition of CD80 by Antigen-Specific CD8⁺ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection
Immune Network
2019 .08
-
CD5 Expression Dynamically Changes During the Differentiation of Human CD8+ T Cells Predicting Clinical Response to Immunotherapy
Immune Network
2023 .08
-
Leukemia propagating cells in Philadelphia chromosome-positive ALL: a resistant phenotype with an adverse prognosis
Blood Research
2018 .01
-
Two Distinct Subsets Are Identified from the Peritoneal Myeloid Mononuclear Cells Expressing both CD11c and CD115
Immune Network
2019 .06
-
Prognostic Significance of CD109 Expression in Patients with Ovarian Epithelial Cancer
Journal of Pathology and Translational Medicine
2019 .01
-
Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: is it different between Over and Under 50 Years of Age?
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
Immune Network
2023 .10
-
Cluster Containing More Than 20 CD3-Positive Cells in Bone Marrow Biopsy Is a Candidate Prognostic Indicator in Peripheral T-Cell Lymphoma, Not Otherwise Specified
Annals of Laboratory Medicine
2019 .01
-
Effect of Peripheral Blood CD4 + CD25 + Regulatory T Cell on Postoperative Immunotherapy for Patients with Renal Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
CD9 Expression in Colorectal Carcinomas and Its Prognostic Significance
Journal of Pathology and Translational Medicine
2016 .01
-
Stem Cell Markers Predict the Response to Sorafenib in Patients with Hepatocellular Carcinoma
Gut and Liver
2019 .01
-
POEMS Syndrome: Bone Marrow, Laboratory, and Clinical Findings in 24 Korean Patients
Annals of Laboratory Medicine
2019 .01
-
Changes in serum levels of lipopolysaccharides and CD26 in patients with Crohn’s disease
Intestinal research
2017 .01
-
Diffuse large B-cell lymphoma (DLBCL) is infiltrated with activated CD8+ T-cells despite immune checkpoint signaling
Blood Research
2022 .06
-
mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer
Yonsei Medical Journal
2020 .01
-
Effector Memory CD8+ and CD4+ T Cell Immunity Associated with Metabolic Syndrome in Obese Children
Pediatric Gastroenterology, Hepatology & Nutrition
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0